ChemicalBook > CAS DataBase List > THIOPHENE-2-THIOCARBOXAMIDE

THIOPHENE-2-THIOCARBOXAMIDE

Product Name
THIOPHENE-2-THIOCARBOXAMIDE
CAS No.
20300-02-1
Chemical Name
THIOPHENE-2-THIOCARBOXAMIDE
Synonyms
THIOPHENE-2-CARBOTHIOAMIDE;THIOPHENE-2-THIOAMIDE;OTAVA-BB BB7020331311;2-Thiocarbamoylthiophene;2-Thienylthiocarboxamide;2-Thiophenecarbothioamide;Thiophen-2-carbothioamide;Thiophen-2-thiocarboxamid;2-Thiophenethiocarboxamide;THIOPHENE-2-THIOCARBOXAMIDE
CBNumber
CB5697863
Molecular Formula
C5H5NS2
Formula Weight
143.23
MOL File
20300-02-1.mol
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THIOPHENE-2-THIOCARBOXAMIDE Property

Melting point:
106 °C
Boiling point:
260℃
Density 
1.357
Flash point:
111℃
storage temp. 
2-8°C(protect from light)
form 
powder to crystal
pka
12.56±0.29(Predicted)
color 
White to Yellow to Green
Water Solubility 
Insoluble in water.
BRN 
110159
CAS DataBase Reference
20300-02-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
25-43
Safety Statements 
22-36/37/39-45-36/37
RIDADR 
2811
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS014286
Product name
Thiophene-2-carbothioamide
Purity
Aldrich<SUP>CPR</SUP>
Packaging
250 mg
Price
$73.1
Updated
2025/07/31
TCI Chemical
Product number
T3604
Product name
Thiophene-2-carbothioamide
Purity
>98.0%(HPLC)
Packaging
5g
Price
$407
Updated
2025/07/31
TCI Chemical
Product number
T3604
Product name
Thiophene-2-carbothioamide
Purity
>98.0%(HPLC)
Packaging
25g
Price
$1286
Updated
2025/07/31
TRC
Product number
T430110
Product name
Thiophene-2-thiocarboxamide
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
T430110
Product name
Thiophene-2-thiocarboxamide
Packaging
50mg
Price
$60
Updated
2021/12/16
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THIOPHENE-2-THIOCARBOXAMIDE Chemical Properties,Usage,Production

Uses

Thiophene-2-thiocarboxamide is used as a pharmaceutical intermediate.

Synthesis

5813-89-8

20300-02-1

General procedure for the synthesis of thiophene-2-thioformamide from 2-thiophenecarboxamide: 2-thiophenecarboxamide (1 g, 7.86 mmol) was dissolved in dry 1,2-dimethoxyethane (30 mL). Lawesson's reagent (1.6 g, 3.9 mmol) was added and the reaction was protected under nitrogen. The reaction mixture was stirred at room temperature for 12 hours and then filtered. Subsequently, the solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10:1 to 2:1) to afford thiophene-2-thiocarboxamide (1.0 g, 88.8% yield, white solid). Thiophene-2-carbothioamide can be used directly in the subsequent reaction without further purification.

References

[1] Patent: EP2708534, 2014, A1. Location in patent: Paragraph 0055
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 904 - 908
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 17, p. 7512 - 7523
[4] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9655 - 9662
[5] Journal of Chemical Research, 2010, # 3, p. 151 - 153

THIOPHENE-2-THIOCARBOXAMIDE Preparation Products And Raw materials

Raw materials

N-Methyl-2-pyrrolidone 2-Thiophenecarboxaldehyde N,N-Dimethylformamide Hydroxylamine hydrochloride Sodium hydrosulfide Magnesium chloride hexahydrate

Preparation Products

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THIOPHENE-2-THIOCARBOXAMIDE Suppliers

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View Lastest Price from THIOPHENE-2-THIOCARBOXAMIDE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
THIOPHENE-2-THIOCARBOXAMIDE 20300-02-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29
Shaanxi Dideu Medichem Co. Ltd
Product
Thiophene-2-carbothioic acid amide 20300-02-1
Price
US $0.01-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-04-22
Shanghai Rlavie Technology Co ltd
Product
Thiophene-2-thiocarboxamide 20300-02-1
Price
US $0.00/KG
Min. Order
1g
Purity
98%minHPLC
Supply Ability
50kgs/month
Release date
2021-11-16

20300-02-1, THIOPHENE-2-THIOCARBOXAMIDERelated Search:

THIOPHENE-3-THIOCARBOXAMIDE THIFLUZAMIDE 3-Thiopheneboronic acid 3-THIOPHENECARBOXYLIC ACID HYDRAZIDE 5,5-Dimethyl-2-(thiophen-2-yl)-1,3,2-dioxaborinane Thiophene-2,3-dicarboxylicacid Dimethyl thiophene-2,3-dicarboxylate Thiazolyl Blue Pseudothiohydantoin 2,5-Bis-Thiopheneboronic acid pinacol ester Thiophene-2,3-dicarboxylic acid THIENO[3,2-B]PYRIDINE Ethylthiophene-2-carboximidoatehydrochloride ETHYL THIOPHENE-2-GLYOXYLATE 2(5 H)-THIOPHENONE 2-Thiophenesulfonic acid (2-methylphenyl)(thien-2-yl)methanone 3-AMinothiophene Oxalate

  • OTAVA-BB BB7020331311
  • THIOPHENE-2-THIOAMIDE
  • THIOPHENE-2-THIOCARBOXAMIDE
  • THIOPHENE-2-CARBOTHIOAMIDE
  • THIOPHENE-2-CARBOTHIOIC ACID AMIDE
  • Thiophene-2-carbothioamide, 95+%
  • Thiophene-2-carbothioic acid amide, 2-Carbamothioylthiophene
  • 2-(Aminothiocarbonyl)thiophene
  • 2-Thienylthiocarboxamide
  • 2-Thiocarbamoylthiophene
  • 2-Thiophenecarbothioamide
  • 2-Thiophenethiocarboxamide
  • Thiophen-2-carbothioamide
  • thiohypofluorous acid (4-oxo-3,4-dihydro-2H-1-benzopyran-6-yl) ester
  • Thiophen-2-thiocarboxamid
  • Thiophene-2-thiocarboxamide-97%
  • 20300-02-1