GOT1 inhibitor 2c
- Product Name
- GOT1 inhibitor 2c
- CAS No.
- 732973-87-4
- Chemical Name
- GOT1 inhibitor 2c
- Synonyms
- GOT1 inhibitor-1;GOT1 inhibitor 2c;GOT1 inhibitor-1, 10 mM in DMSO;N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide;1-Piperazinecarboxamide, N-(4-chlorophenyl)-4-(1H-indol-4-yl)-;GOT1 inhibitor1,inhibit,GOT-1 inhibitor-1,glutamate-oxaloacetate transaminase 1,Cancer,Pancreatic,GOT1,metabolism,?Aspartate aminotransferase-1,ductal,Inhibitor,GOT1 inhibitor 1,PDAC,adenocarcinoma,GOT1 inhibitor-1
- CBNumber
- CB58059447
- Molecular Formula
- C19H19ClN4O
- Formula Weight
- 354.83
- MOL File
- 732973-87-4.mol
GOT1 inhibitor 2c Property
- Boiling point:
- 639.5±55.0 °C(Predicted)
- Density
- 1.387±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 125 mg/mL (352.28 mM)
- pka
- 13.07±0.70(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- Water Solubility
- Water: < 0.1 mg/mL (insoluble)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CSN27598
- Product name
- GOT1inhibitor2c
- Packaging
- 1mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CSN27598
- Product name
- GOT1inhibitor2c
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CSN27598
- Product name
- GOT1inhibitor2c
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CSN27598
- Product name
- GOT1inhibitor2c
- Packaging
- 25mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- DC12542
- Product name
- GOT1inhibitor2c
- Purity
- >98%
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
GOT1 inhibitor 2c Chemical Properties,Usage,Production
Uses
GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC)[1].
References
[1] Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678 DOI:10.1016/j.bmcl.2018.04.061
[2] Sun W, et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun Signal. 2019;17(1):111. DOI:10.1186/s12964-019-0425-4
GOT1 inhibitor 2c Preparation Products And Raw materials
Raw materials
Preparation Products
GOT1 inhibitor 2c Suppliers
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