Cusatuzumab

Product Name: Cusatuzumab
CAS No.: 1399546-01-0
Chemical Name: Cusatuzumab
Synonyms: Cusatuzumab;Research Grade Cusatuzumab;Research Grade Cusatuzumab(DHE01901)
CBNumber: CB58081071
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Cusatuzumab Chemical Properties,Usage,Production

Description

Cusatuzumab is designed as a first-in-class, high-affinity anti-CD70 monoclonal antibody with multiple intended mechanisms of action, including Fc-mediated cytotoxicity with enhanced ADCC and inhibition of CD70/CD27 signaling, resulting in killing of malignant cells such as leukemia blasts and stem cells.

Definition

cusatuzumab is a defucosylated, humanized IgG1 monoclonal antibody directed against the extracellular domain of the human CD70 molecule with potential antineoplastic activity. Upon administration, cusatuzumab selectively binds to, and neutralizes the activity of CD70, which may also induce an antibody-dependent cellular cytotoxicity (ADCC) response against CD70-expressing tumor cells. CD70, the ligand for the costimulatory receptor CD27 and a member of the tumor necrosis factor (TNF) family, is found on a number of solid and hematological tumors. Its overexpression may play an important role in evasion of immune surveillance.
Synonym: anti-CD70 monoclonal antibody ARGX-110
Code name: ARGX-110

Cusatuzumab Preparation Products And Raw materials

Raw materials

Preparation Products

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Cusatuzumab Suppliers

China 12 Global 12

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
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Guangzhou Hongyuan Chemical Co.,Ltd

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Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
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Biolab Reagents

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Wuhan Jingkangen Biomedical Technology Co., Ltd

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Shanghai Yifei Biotechnology Co. , Ltd.

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Changsha Fuzhen Biotechnology Co.，LTD

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Atagenix Laboratories

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AntibodySystem Laboratories SAS

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Cell Sciences

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Guangzhou Chuangze Biotechnology Co., Ltd.

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Guangzhou Lucheng Biotechnology Co., Ltd.

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1399546-01-0, CusatuzumabRelated Search:

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Cusatuzumab

Research Grade Cusatuzumab(DHE01901)

Research Grade Cusatuzumab

1399546-01-0