K114
- Product Name
- K114
- CAS No.
- 872201-12-2
- Chemical Name
- K114
- Synonyms
- K114;K114,K-114;(trans,trans)-1-bromo-2,5-bis-(4-hydroxy)styrylbenzene;K114,(trans,trans)-1-Bromo-2,5-bis-(4-hydroxy)styrylbenzene;4,4'-[(2-Bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol;Phenol, 4,4'-[(2-bromo-1,4-phenylene)di-(1E)-2,1-ethenediyl]bis-;4,4'-((1E,1'E)-(2-bromo-1,4-phenylene)bis(ethene-2,1-diyl))diphenol
- CBNumber
- CB5972713
- Molecular Formula
- C22H17BrO2
- Formula Weight
- 393.27
- MOL File
- 872201-12-2.mol
K114 Property
- Boiling point:
- 563.0±39.0 °C(Predicted)
- Density
- 1.462±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: soluble >10mg/mL
- form
- powder
- pka
- 9.92±0.26(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3144
- Product name
- K114
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $123
- Updated
- 2021/12/16
- Product number
- 3144
- Product name
- K114
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $515
- Updated
- 2021/12/16
- Product number
- K000450
- Product name
- K114
- Packaging
- 10mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 255576
- Product name
- K 114
- Packaging
- 10mg
- Price
- $366
- Updated
- 2021/12/16
- Product number
- CS-0027952
- Product name
- K114
- Purity
- >99.0%
- Packaging
- 2mg
- Price
- $110
- Updated
- 2021/12/16
K114 Chemical Properties,Usage,Production
Description
K 114 is a potent amyloid fibril-specific fluorescent dye (EC50 = 20-30 nM).
Uses
K 114 is a potent amyloid fibril-specific fluorescent dye. K 114 is a potent amyloid fibril-specific fluorescent dye similar to Congo Red and BSB. K 114 recognizes amyloid lesions and facilitates quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. The affinity for fibrils ranges 20-30 nM. Unlike the other compounds K114 has minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils. K114 can be used to monitor in vitro amyloid fibril formation by fluorescence emission at 550 nm.
Definition
ChEBI: (E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene is an organobromine compound that is bromobenzene in which the hydrogens at positions 2 and 5 are replaced by 4-hydroxystyryl groups. It has a role as a fluorescent dye. It is an organobromine compound and a polyphenol.
Biological Activity
Potent amyloid fibril-specific fluorescent dye (EC 50 = 20 - 30 nM). Exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of A β , α -synuclein and tau in situ . (Optimum wavelength = 550 nM).
storage
Store at +4°C
K114 Preparation Products And Raw materials
Raw materials
Preparation Products
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