K114

K114 Property

Boiling point:

563.0±39.0 °C(Predicted)

Density 

1.462±0.06 g/cm3(Predicted)

storage temp. 

Store at +4°C

solubility 

DMSO: soluble >10mg/mL

form 

powder

pka

9.92±0.26(Predicted)

color 

white to beige

Safety

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

K114 Chemical Properties,Usage,Production

Description

K 114 is a potent amyloid fibril-specific fluorescent dye (EC50 = 20-30 nM).

Uses

K 114 is a potent amyloid fibril-specific fluorescent dye. K 114 is a potent amyloid fibril-specific fluorescent dye similar to Congo Red and BSB. K 114 recognizes amyloid lesions and facilitates quantitative monitoring of the formation of amyloid fibrils assembled from the Aβ peptide, α-synuclein, and tau. The affinity for fibrils ranges 20-30 nM. Unlike the other compounds K114 has minimal fluorescence in aqueous buffers, but fluoresces brightly in the presence of amyloid fibrils. K114 can be used to monitor in vitro amyloid fibril formation by fluorescence emission at 550 nm.

Definition

ChEBI: (E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene is an organobromine compound that is bromobenzene in which the hydrogens at positions 2 and 5 are replaced by 4-hydroxystyryl groups. It has a role as a fluorescent dye. It is an organobromine compound and a polyphenol.

Biological Activity

Potent amyloid fibril-specific fluorescent dye (EC 50 = 20 - 30 nM). Exhibits minimal fluorescence in aqueous buffers and fluoresces brightly in the presence of A β , α -synuclein and tau in situ . (Optimum wavelength = 550 nM).

storage

Store at +4°C