ATC 0175

Product Name: ATC 0175
CAS No.: 510733-97-8
Chemical Name: ATC 0175
Synonyms: ATC 0175 HCl;ATC 0175 hydrochloride;N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloride;Rel-N-((1s,4s)-4-((4-(dimethylamino)quinazolin-2-yl)amino)cyclohexyl)-3,4-difluorobenzamide hydrochloride
CBNumber: CB5972935
Molecular Formula: C23H25F2N5O.ClH
Formula Weight: 461.941
MOL File: 510733-97-8.mol

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ATC 0175 Property

storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL
form: solid
color: White to light yellow

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3355
Product name: ATC0175
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $436
Updated: 2025/07/31

Tocris

Product number: 3346
Product name: ATC0175hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $220
Updated: 2021/12/16

Tocris

Product number: 3346
Product name: ATC0175hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $897
Updated: 2021/12/16

TRC

Product number: A790540
Product name: ATC0175
Packaging: 25mg
Price: $530
Updated: 2021/12/16

TRC

Product number: A790540
Product name: ATC0175
Packaging: 10mg
Price: $265
Updated: 2021/12/16

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ATC 0175 Chemical Properties,Usage,Production

Uses

ATC0175 is a MCHR1, SR-1A and SR-2B inhibitor.

Biological Activity

Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH 1 ) antagonist (IC 50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT 2B and 5-HT 1A receptors (IC 50 values are 9.66 and 16.9 nM respectively).

in vitro

assays showed that this compound is a potent antagonist with a high affinity for mch1r. the receptor binding and the functional assay (mch-induced increase in [ca2+]) indicated that atc0175 is a noncompetitive antagonist at mch1rs 1.

in vivo

atc0175 displayed anxiolytic effects in numerous animal models of anxiety including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization and stress-induced hyperthermia. in addition, atc0175 treatment also exhibited antidepressant effects in the forced swimming test 2.

References

1. semple g, tran ta, kramer b, et al. pyrimidine-based antagonists of h-mch-r1 derived from atc0175: in vitro profiling and in vivo evaluation. bioorganic & medicinal chemistry letters. 2009;19(21):6166-6171.2. chaki s, yamaguchi j, yamada h, et al. atc0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. cns drug reviews. 2005;11(4):341-352.

ATC 0175 Preparation Products And Raw materials

Raw materials

Preparation Products

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ATC 0175 Suppliers

China 28 Switzerland 1 United Kingdom 1 United States 6 USA 1 Global 37

3B Pharmachem (Wuhan) International Co.,Ltd.

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510733-97-8, ATC 0175Related Search:

ATC 0175 hydrochloride

N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloride

ATC 0175 HCl

Rel-N-((1s,4s)-4-((4-(dimethylamino)quinazolin-2-yl)amino)cyclohexyl)-3,4-difluorobenzamide hydrochloride

510733-97-8

C23H26ClF2N5O

C23H25F2N5OHCl