ATC 0175
- Product Name
- ATC 0175
- CAS No.
- 510733-97-8
- Chemical Name
- ATC 0175
- Synonyms
- ATC 0175 HCl;ATC 0175 hydrochloride;N-[cis-4-[[4-(Dimethylamino)-2-quinazolinyl]amino]cyclohexyl]-3,4-difluorobenzamidehydrochloride;Rel-N-((1s,4s)-4-((4-(dimethylamino)quinazolin-2-yl)amino)cyclohexyl)-3,4-difluorobenzamide hydrochloride
- CBNumber
- CB5972935
- Molecular Formula
- C23H25F2N5O.ClH
- Formula Weight
- 461.941
- MOL File
- 510733-97-8.mol
ATC 0175 Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble5mg/mL
- form
- solid
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3355
- Product name
- ATC0175
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $436
- Updated
- 2025/07/31
- Product number
- 3346
- Product name
- ATC0175hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 3346
- Product name
- ATC0175hydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $897
- Updated
- 2021/12/16
- Product number
- A790540
- Product name
- ATC0175
- Packaging
- 25mg
- Price
- $530
- Updated
- 2021/12/16
- Product number
- A790540
- Product name
- ATC0175
- Packaging
- 10mg
- Price
- $265
- Updated
- 2021/12/16
ATC 0175 Chemical Properties,Usage,Production
Uses
ATC0175 is a MCHR1, SR-1A and SR-2B inhibitor.
Biological Activity
Potent, selective and orally active melanin-concentrating hormone receptor 1 (MCH 1 ) antagonist (IC 50 values are 13.5 and > 10000 nM for MCH1 and MCH2 receptors respectively). Exhibits anxiolytic and antidepressant activity in rodents. Also displays affinity for 5-HT 2B and 5-HT 1A receptors (IC 50 values are 9.66 and 16.9 nM respectively).
in vitro
assays showed that this compound is a potent antagonist with a high affinity for mch1r. the receptor binding and the functional assay (mch-induced increase in [ca2+]) indicated that atc0175 is a noncompetitive antagonist at mch1rs 1.
in vivo
atc0175 displayed anxiolytic effects in numerous animal models of anxiety including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization and stress-induced hyperthermia. in addition, atc0175 treatment also exhibited antidepressant effects in the forced swimming test 2.
References
1. semple g, tran ta, kramer b, et al. pyrimidine-based antagonists of h-mch-r1 derived from atc0175: in vitro profiling and in vivo evaluation. bioorganic & medicinal chemistry letters. 2009;19(21):6166-6171.2. chaki s, yamaguchi j, yamada h, et al. atc0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. cns drug reviews. 2005;11(4):341-352.
ATC 0175 Preparation Products And Raw materials
Raw materials
Preparation Products
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