L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-

Product Name: L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-
CAS No.: 2093305-05-4
Chemical Name: L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-
Synonyms: ATH-1017;Fosgonimeton;Fosgonimeton（ATH-1017）;L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-;4-((S)-3-(((2S,3S)-1-((6-Amino-6-oxohexyl)amino)-3-methyl-1-oxopentan-2-yl)amino)-2-hexanamido-3-oxopropyl)phenyl dihydrogen phosphate
CBNumber: CB59800204
Molecular Formula: C27H45N4O8P
Formula Weight: 584.65
MOL File: 2093305-05-4.mol

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L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- Property

Density: 1.212±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C, protect from light, stored under nitrogen
solubility: DMSO : 125 mg/mL (213.81 mM; Need ultrasonic)
form: Solid
pka: 1.27±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- Chemical Properties,Usage,Production

Uses

Fosgonimeton (ATH-1017) is a hepatocyte growth factor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS (HY-D1056) -induced neuroinflammation and Aβ-induced AD models[1][2][3][4].

in vivo

Fosgonimeton (0.125-2 mg/kg; Subcutaneous injection; 14 days) improves cognitive dysfunction in rat models of AD induced by Aβ^[2].
Fosgonimeton (0.125-1.25 mg/kg; Subcutaneous injection; 14 days) improves cognitive impairment in a LPS (HY-D1056) -induced neuroinflammation model of dementia mice^[3].

Animal Model:	Aβ peptides treated adult male Wistar rats (approximately 210 g)^[2]
Dosage:	0.125 mg/kg, 0.25 mg/kg, 0.5 mg/kg, 1 mg/kg and 2 mg/kg
Administration:	Subcutaneous injection (s.c.); 14 days
Result:	Significantly restored cognitive function at all doses tested. The maximum average degree of recovery was 88% recovery in 0.125 mg/kg treated group.

Animal Model:	LPS (HY-D1056) treated CD-1 mice aged four to five weeks old^[3]
Dosage:	0.125 mg/kg, 0.25 mg/kg, 0.5 mg/kg and 1.25 mg/kg
Administration:	Subcutaneous injection (s.c.); 14 days
Result:	Significantly ameliorated cognitive deficits at all doses tested, except for the lowest dose (0.125 mg/kg) tested.

References

[1] Reda S, et al. Fosgonimeton, a novel, small molecule positive modulator of the HGF/MET system is neuroprotective in primary neuron culture. Alzheimer's Dement. 2022 18: e065874.
[2] Reda SM, et al. Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease. Neurotherapeutics. 2024 Jul;21(4):e00350. DOI:10.1016/j.neurot.2024.e00350
[3] Johnston JL, et al. Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia. Neurotherapeutics. 2023 Mar;20(2):431-451. DOI:10.1007/s13311-022-01325-5
[4] Leen H. KAWAS, et al. WO2017210489. 2021.

L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- manufacturers

Xi an Biohorlden Industry Trade Co Ltd

Product: Fosgonimeton 2093305-05-4
Price: US $0.00-0.00/mg
Min. Order: 50mg
Purity: 99%
Supply Ability: 50g
Release date: 2025-04-28

2093305-05-4, L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-Related Search:

L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-

Fosgonimeton

ATH-1017

Fosgonimeton（ATH-1017）

4-((S)-3-(((2S,3S)-1-((6-Amino-6-oxohexyl)amino)-3-methyl-1-oxopentan-2-yl)amino)-2-hexanamido-3-oxopropyl)phenyl dihydrogen phosphate

2093305-05-4

C27H45N4O8P