Ethyl 4,6-dichloronicotinate

Uses

Product Name: Ethyl 4,6-dichloronicotinate
CAS No.: 40296-46-6
Chemical Name: Ethyl 4,6-dichloronicotinate
Synonyms: ethyl 4,6-dichloropyridine-3-carboxylate;Novobiocin Impurity 5;Ethyl 4,6-dichloronitinate;Ethy14,6-dichloronicotinate;ETHYL 4,6-DICHLORONICOTINATE;Ethyl 4,6-dicholoronicotinate;Ethyl 4,6-Dichloronicotinate >Ethyl 4,6-dichloronicotinate ,97%;ethyl 4,6-dichloronicotinate (en);2,4-Dichloro-5-carbethoxypyridine
CBNumber: CB6102429
Molecular Formula: C8H7Cl2NO2
Formula Weight: 220.05
MOL File: 40296-46-6.mol

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Ethyl 4,6-dichloronicotinate Property

Melting point:: 32-34°
Boiling point:: 85°C/0.01mmHg(lit.)
Density: 1.367±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in methanol.
pka: -1.24±0.10(Predicted)
form: Liquid
color: Yellow
InChI: InChI=1S/C8H7Cl2NO2/c1-2-13-8(12)5-4-11-7(10)3-6(5)9/h3-4H,2H2,1H3
InChIKey: AAUBVINEXCCXOK-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=CC(Cl)=C1C(OCC)=O

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1068
Product name: Ethyl 4,6-Dichloronicotinate
Purity: >98.0%(GC)
Packaging: 1g
Price: $17
Updated: 2025/07/31

TCI Chemical

Product number: E1068
Product name: Ethyl 4,6-Dichloronicotinate
Purity: >98.0%(GC)
Packaging: 5g
Price: $54
Updated: 2025/07/31

TRC

Product number: E915915
Product name: Ethyl 4,6-Dichloronicotinate
Packaging: 250mg
Price: $50
Updated: 2021/12/16

TRC

Product number: E915915
Product name: Ethyl 4,6-Dichloronicotinate
Packaging: 25g
Price: $250
Updated: 2021/12/16

Matrix Scientific

Product number: 046094
Product name: Ethyl 4,6-dichloronicotinate
Purity: 95+%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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Ethyl 4,6-dichloronicotinate Chemical Properties,Usage,Production

Uses

Ethyl 4,6-Dichloronicotinate acts as a reactant in the preparation of (acylamino)aminonaphthyridinones as novobiocin analogs and Hsp90 inhibitors, their antitumor activities in human breast cancer cell lines, and the effects on aptoptosis and cell cycle advancement of selected compounds.

Chemical Properties

White solid

Uses

Ethyl 4,6-dichloronicotinate is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals, and dyestuffs. It is also used as a fine chemical intermediate. Ethyl-4,6-dichloronicotinate could be used as a starting material to synthesize 6-chlorothieno[3,2-c]pyridine-2-carbohydrazide-hydrazone subsidiaries[1].

Synthesis

6975-44-6

40296-46-6

The general procedure for the synthesis of ethyl 4,6-dichloronicotinate from ethyl 4,6-dihydroxynicotinate was as follows: ethyl 4,6-dihydroxynicotinate (60 g, 0.328 mol) was slowly added to phosphorus triclosan (POCl3, 500 mL), followed by heating and refluxing for 2 hours. Upon completion of the reaction, the excess phosphorous trichloride was removed by distillation under reduced pressure. The residue was carefully poured into ice water, stirred for 30 min, and then extracted with ethyl acetate (EtOAc, 3 times). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate (MgSO4) and finally concentrated under vacuum to give ethyl 4,6-dichloronicotinate (65 g, 90% yield). The product was identified by 1H NMR (300 MHz, DMSO-d6): δ 8.80 (s, 1H), 7.95 (s, 1H), 4.34 (q, J=6.9 Hz, 2H), 1.31 (t, J=6.9 Hz, 3H); Mass Spectra (ESI) m/z: 220.1 [M+H]+.

References

[1] N. Rao, K. Prasad, M. Rao. “Synthesis and Antibacterial Evaluation of Hydrazone Derivatives Bearing 6-Chlorothieno[3,2-c]pyridine Moiety.” Asian Journal of Chemistry 1 1 (2019).

Ethyl 4,6-dichloronicotinate Preparation Products And Raw materials

Raw materials

Diethyl 1,3-acetonedicarboxylate Ammonium hydroxide Ethanol Acetic anhydride Triethyl orthoformate Phosphorus oxitrichloride Hydrochloric acid Sodium hydroxide

Preparation Products

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View Lastest Price from Ethyl 4,6-dichloronicotinate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Ethyl 4,6-dichloronicotinate 40296-46-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-11-13

Hebei Chuanghai Biotechnology Co., Ltd

Product: Ethyl 4,6-dichloronicotinate 40296-46-6
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Henan Aochuang Chemical Co.,Ltd.

Product: Ethyl 4,6-dichloronicotinate 40296-46-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

40296-46-6, Ethyl 4,6-dichloronicotinateRelated Search:

Ethyl acetoacetate 4,6-Dichloronicotinic acid 6-Chloronicotinic acid Ethyl pyruvate Ethyl acrylate Thionyl chloride Ethyl oleate Ethyl acetate Ethanol 2-Chloronicotinic acid Ethyl nicotinate 2,5-Dichloronicotinic acid 2,6-Dichloronicotinic acid Tris(trimethylsilyl)phosphate 5,6-Dichloronicotinic acid Ethyl formate Ethyl cyanoacetate Ethylparaben

4,6-Dichloronicotinic acid ethyl ester ,97%

ethyl 4,6-dichloronicotinate (en)

Ethyl 4,6-dichloronicotinate ,97%

ethyl 4,6-dichloropyridine-3-carboxylate

3-Pyridinecarboxylicacid,4,6-dichloro-,ethylester

4,6-DICHLOROPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

4,6-DICHLORONICOTINIC ACID ETHYL ESTER

ETHYL 4,6-DICHLORONICOTINATE

2,4-Dichloro-5-carbethoxypyridine

2,4-dichloropyridin-5-carboxylic acid,ethyl ester

Ethyl 4,6-dicholoronicotinate

Ethyl 4,6-dichloropyridine-3-carboxylate, 2,4-Dichloro-5-(ethoxycarbonyl)pyridine

Ethyl 4,6-Dichloronicotinate &gt

Ethyl 4,6-dichloronitinate

Novobiocin Impurity 5

Ethyl 4,6-dichloronicotinate ISO 9001：2015 REACH

Ethyl 4,6-dichloro-3-pyridinecarboxylate

Ethy14,6-dichloronicotinate

Ethyl 4,6-dichloronicotinate(Ethyl 4,6-dichloronicotinate)

40296-46-6

Pyridine series

Boronic Acid