Benzenamine, 2-ethynyl-4-methyl- (9CI)

Benzenamine, 2-ethynyl-4-methyl- (9CI) Property

Boiling point:

241.8±33.0 °C(Predicted)

Density 

1.03±0.1 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

form 

solid

pka

2.44±0.10(Predicted)

Safety

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

26

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Benzenamine, 2-ethynyl-4-methyl- (9CI) Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 2-ethynyl-4-methylaniline from the compound (CAS: 180624-14-0): to a stirred 2:1 MeOH/Et2O (250 mL) solution of 2-ethynyl-4-methylaniline (22) (11.32 g, 55.6 mmol) was added, at room temperature, K2CO3 (15.38 g, 111 mmol ). After stirring at this temperature for 1 h, the reaction mixture was diluted with water and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered and concentrated under reduced pressure to afford 2-alkynyl-4-methylaniline (23) as a light brown solid without further purification (6.79 g, 93%).1H NMR (300 MHz, CDCl3) δ 7.14 (d, J = 1.5 Hz, 1H), 6.96 (dd, J = 8.2, 1.5 Hz, 1H), 6.62 (d, J = 8.2, 1.5 Hz, 1H) 6.62 (d, J = 8.2 Hz, 1H), 4.11 (s, 2H), 3.36 (s, 1H), 2.21 (s, 3H).

References

[1] Patent: US2014/31559, 2014, A1. Location in patent: Paragraph 0272
[2] Journal of Organic Chemistry, 2006, vol. 71, # 9, p. 3653 - 3655
[3] Synlett, 2006, # 1, p. 65 - 68
[4] Angewandte Chemie - International Edition, 2007, vol. 46, # 12, p. 2074 - 2077
[5] Journal of Organic Chemistry, 2008, vol. 73, # 11, p. 4160 - 4165