ChemicalBook > CAS DataBase List > Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-

Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-

Product Name: Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-
CAS No.: 2377352-49-1
Chemical Name: Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-
Synonyms: SHP-1971;GDC-1971;Migoprotafib;GDC-1971 (RLY-1971);Migoprotafib (GDC-1971);(R)-1'-(3-(3,4-Dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-amine;(R)-1'-(3-(3,4-Dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-amine;Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-
CBNumber: CB610860058
Molecular Formula: C25H26N8O
Formula Weight: 454.54
MOL File: 2377352-49-1.mol

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Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)- Property

Boiling point:: 714.1±60.0 °C(Predicted)
Density: 1.48±0.1 g/cm3(Predicted)
solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Methanol: Sparingly soluble: 1-10 mg/ml
form: Solid
pka: 9.52±0.50(Predicted)
color: Light yellow to yellow
InChIKey: RGCGBFIARQENML-ZEGQKUPANA-N
SMILES: N[C@@H]1C2=CC=CC=C2OC21CCN(C1=CN=C3C(N4CCCC5=NC=CC=C45)=NNC3=N1)CC2 |&1:1,r|

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Hazard and Precautionary Statements (GHS)

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Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)- Chemical Properties,Usage,Production

Description

Migoprotafib is a protein tyrosine phosphate, also known as HPTP, inhibitor with potential as an antineoplastic agent.

Uses

Migoprotafib (GDC-1971) (compound 199) is a SHP2 inhibitor. Migoprotafib inhibits the MAPK/ERK signaling pathway, and exhibits antitumor activity[1][2].

in vivo

Migoprotafib (60 mg/kg, po for 28 days) exhibits antitumor efficacy in RIT1 xenograft mouse models^[2].

Animal Model:	RIT1 xenograft mouse models^[2]
Dosage:	60 mg/kg
Administration:	po for 28 days
Result:	Inhibited tumor growth.

References

[1] Alexander M, et al. Shp2 phosphatase inhibitors and methods of use thereof. Patent WO2019183367A1.
[2] Maddalo D, et al. RIT1M90I is a driver of lung adenocarcinoma tumorigenesis and resistance to targeted therapy[J]. 2024.
[3] ALEXANDER M. TAYLOR*, LINDSAY WILLMORE Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors[J]. Journal of Medicinal Chemistry, 2023, 66 19: 13384-13399. DOI: 10.1021/acs.jmedchem.3c00483

Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2377352-49-1, Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-Related Search:

Spiro[benzofuran-2(3H),4'-piperidin]-3-amine, 1'-[3-(3,4-dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-, (3R)-

GDC-1971

SHP-1971

GDC-1971 (RLY-1971)

Migoprotafib (GDC-1971)

Migoprotafib

(R)-1'-(3-(3,4-Dihydro-1,5-naphthyridin-1(2H)-yl)-1H-pyrazolo[3,4-b]pyrazin-6-yl)-3H-spiro[benzofuran-2,4'-piperidin]-3-amine

2377352-49-1