(5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acid

Product Name: (5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acid
CAS No.: 183509-22-0
Chemical Name: (5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acid
Synonyms: 16(R)-HETE;JEKNPVYFNMZRJG-STHMYGMFSA-N;16(R)-hydroxy-5(Z),8(Z),11(Z),14(Z)-ETA;16(R)-hydroxy-5(Z),8(Z),11(Z),14(Z)-eicosatetraenoic acid;(5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acid;5,8,11,14-Eicosatetraenoic acid, 16-hydroxy-, (5Z,8Z,11Z,14Z,16R)-
CBNumber: CB61235342
Molecular Formula: C20H32O3
Formula Weight: 320.47
MOL File: 183509-22-0.mol

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(5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acid Property

Boiling point:: 477.3±45.0 °C(Predicted)
Density: 0.984±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
pka: 4.75±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10004385
Product name: 16(R)-HETE
Purity: ≥98%
Packaging: 25μg
Price: $146
Updated: 2024/03/01

Cayman Chemical

Product number: 10004385
Product name: 16(R)-HETE
Purity: ≥98%
Packaging: 50μg
Price: $278
Updated: 2024/03/01

Cayman Chemical

Product number: 10004385
Product name: 16(R)-HETE
Purity: ≥98%
Packaging: 100μg
Price: $525
Updated: 2024/03/01

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(5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acid Chemical Properties,Usage,Production

Description

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 16-HETE is a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation that demonstrates stereospecific biological activity. 16(R)-HETE inhibits proximal tubule ATPase activity by as much as 60% at a concentration of 2 μM.

Uses

16(R)-HETE, a metabolite of the cytochrome P450 branch of the arachidonate cascade, is a vasodilator[1].

Definition

ChEBI: 16(R)-HETE is a 16-HETE in which the chiral centre at position 16 has R-configuration. It has a role as a mouse metabolite. It is a conjugate acid of a 16(R)-HETE(1-). It is an enantiomer of a 16(S)-HETE.

References

[1] Reddy YK, et al. Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3719-20. DOI:10.1016/j.bmcl.2003.08.005

(5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acid Preparation Products And Raw materials

Raw materials

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183509-22-0, (5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acidRelated Search:

(5Z,8Z,11Z,14Z,16R)-16-hydroxyicosa-5,8,11,14-tetraenoic acid

16(R)-HETE

JEKNPVYFNMZRJG-STHMYGMFSA-N

16(R)-hydroxy-5(Z),8(Z),11(Z),14(Z)-eicosatetraenoic acid

5,8,11,14-Eicosatetraenoic acid, 16-hydroxy-, (5Z,8Z,11Z,14Z,16R)-

16(R)-hydroxy-5(Z),8(Z),11(Z),14(Z)-ETA

183509-22-0