3'-fluoro-3'-deoxyadenosine
- Product Name
- 3'-fluoro-3'-deoxyadenosine
- CAS No.
- 75059-22-2
- Chemical Name
- 3'-fluoro-3'-deoxyadenosine
- Synonyms
- 3'-F-3'-rA;3'-fluoro-3'-deoxyadenosine;3'-fluoro-3'-deoxyadenosine;3’-Deoxy-3’-fluoro adenosine;Adenosine, 3'-deoxy-3'-fluoro-;(2R,3S,4S,5R)-2-(6-Amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol
- CBNumber
- CB61333211
- Molecular Formula
- C10H12FN5O3
- Formula Weight
- 269.23
- MOL File
- 75059-22-2.mol
3'-fluoro-3'-deoxyadenosine Property
- Melting point:
- 211-212 °C
- Boiling point:
- 628.6±65.0 °C(Predicted)
- Density
- 2.01±0.1 g/cm3(Predicted)
- pka
- 12.45±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C10H12FN5O3/c11-5-4(1-17)19-10(7(5)18)16-3-15-6-8(12)13-2-14-9(6)16/h2-5,7,10,17-18H,1H2,(H2,12,13,14)/t4-,5-,7-,10-/m1/s1
- InChIKey
- QCDAWXDDXYQEJJ-QYYRPYCUSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1F
N-Bromosuccinimide Price
- Product number
- D239975
- Product name
- 3''-Deoxy-3''-fluoroadenosine
- Packaging
- 10mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- ND15616
- Product name
- 3'-Deoxy-3'-fluoroadenosine
- Packaging
- 5mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- ND15616
- Product name
- 3'-Deoxy-3'-fluoroadenosine
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 8706CA
- Product name
- 3'-Fluoro-3'-deoxyadenosine
- Packaging
- 5mg
- Price
- $151
- Updated
- 2021/12/16
- Product number
- ND15616
- Product name
- 3'-Deoxy-3'-fluoroadenosine
- Packaging
- 25mg
- Price
- $225
- Updated
- 2021/12/16
3'-fluoro-3'-deoxyadenosine Chemical Properties,Usage,Production
Uses
3'-deoxy-3'-fluoroadenosine can be used as pharmaceutical intermediates for pharmaceutical experimental research.
Biological Activity
3'-Fluoro-3'-deoxyadenosine was active against a broad range of viruses, encompassing both DNA viruses [pox (vaccinia)], single-stranded (+) RNA viruses [picorna (polio, Coxsackie B), toga (sindbis, Semliki Forest)] and double-stranded RNA viruses (reo). Its antiviral activity spectrum, 3'-fluoro-3'-deoxyadenosine, clearly differed from those adenosine analogs known as inhibitors of S-adenosylhomocysteine hydrolase. 3'-Fluoro-3'-deoxyadenosine also proved effective in vivo in inhibiting tail lesion formation in mice inoculated intravenously with vaccinia virus[1].
References
[1] A. Van Aerschot. “Synthesis and antiviral activity evaluation of 3′-fluoro-3′-deoxyribonucleosides: broad-spectrum antiviral activity of 3′-fluoro-3′-deoxyadenosine.” Antiviral research 12 3 (1989): Pages 133-150.
3'-fluoro-3'-deoxyadenosine Preparation Products And Raw materials
Raw materials
Preparation Products
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