DEBRISOQUIN SULFATE

Product Name: DEBRISOQUIN SULFATE
CAS No.: 581-88-4
Chemical Name: DEBRISOQUIN SULFATE
Synonyms: Tendor;declinax;RO 5-3307;RO 5-33071;Debrisoquina;Debrisochinum;ebrisoquinsulfate;DEBRISOQUIN SULFATE;DEBRISOQUINE SULFATE;isocaramidinesulfate
CBNumber: CB6133940
Molecular Formula: C20H28N6O4S
Formula Weight: 448.54
MOL File: 581-88-4.mol

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DEBRISOQUIN SULFATE Property

Melting point:: 278-280°, 284-285° or 266-268° (H2O)
storage temp.: room temp
solubility: H₂O: 20 mg/mL with heat
form: Solid
color: Pale Yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 26-36
WGK Germany: 3
RTECS: NW7010000
Toxicity: LD50 in neonate, adult rats (mg/kg): 88 ±18, 1580 ±163 orally (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D1306
Product name: Debrisoquine sulfate
Packaging: 100mg
Price: $280
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP103
Product name: Debrisoquine sulfate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $266
Updated: 2024/03/01

Cayman Chemical

Product number: 29568
Product name: Debrisoquin (hemisulfate)
Packaging: 10mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 29568
Product name: Debrisoquin (hemisulfate)
Packaging: 250mg
Price: $595
Updated: 2024/03/01

Cayman Chemical

Product number: 29568
Product name: Debrisoquin (hemisulfate)
Packaging: 50mg
Price: $155
Updated: 2024/03/01

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DEBRISOQUIN SULFATE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Declinax,Roche,UK,1967

Uses

Antihypertensive.

Manufacturing Process

27 g of 1,2,3,4-tetrahydroisoquinoline was added at room temperature to a solution of 28 g of 2-methyl-2-isothiourea sulfate in 80 ml of water. The resulting mixture was kept at room temperature with occasional shaking. After a short period of time, methylmercaptan began to escape, and the mixture warmed up slightly. After then standing for 24 hours, crystals formed. They were filtered off and rinsed with ice cold water. Recrystallization from approximately 100 ml of water yielded 1,2,3,4-tetrahydroisoquinoline-2- carboxamidine sulfate melting at 278°C to 280°C (uncorr.).
Another batch prepared in the same manner melted at 284°C to 285°C due to a minute difference in moisture content.
Both batches prepared above analyzed correctly for (C10H13N3)2·H2SO4.

brand name

Declinax (HoffmannLaRoche).

Therapeutic Function

Antihypertensive

Biochem/physiol Actions

Debrisoquine is an anti-hypertensive agent. It is metabolized by cytochrome P4502D6.

DEBRISOQUIN SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

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DEBRISOQUIN SULFATE Suppliers

Canada 1 China 20 Germany 1 Switzerland 1 United Kingdom 2 United States 9 Global 34

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Changzhou Furuisi Biotechnology Co., Ltd

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InvivoChem

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581-88-4, DEBRISOQUIN SULFATERelated Search:

FERROUS SULFATE DEBRISOQUIN SULFATE--N/H BENZYLGUANIDINE SULFATE (2:1) debrisoquine 1,1-DIMETHYLGUANIDINE SULFATE CHEMBRDG-BB 4015994 rac 4-Hydroxydebrisoquine Hemisulfate DEBRISOQUIN SULFATE 1,1-DIETHYLGUANIDINE SULFATE N'-BENZYLGUANIDINEACETATE 1-METHYLGUANIDINE SULFATE N-ETHYLGUANIDINIUM SULFATE

3,4-dihydro-2(1h)-isoquinolinecarboximidamidsulfate(2:1)

3,4-dihydro-2(1h)-isoquinolinecarboxamidinsulfate(2:1)

3,4-Dihydro-2(1H)-isoquinolinecarboximidamide, Debrisoquin sulfate, Ro5-33071

Tendor

3,4-Dihydro-2(1H)-isoquinolinecarboxamide hemisulfate

3,4-DIHYDRO-2(1H)-ISOQUINOLINECARBOXAMIDINE 0.5 H2SO4

3,4-DIHYDRO-2-[1H]-ISOQUINOLINECARBOXAMIDINE SULFATE SALT

DEBRISOQUINE SULFATE

DEBRISOQUIN SULFATE

bis(2-amidino-1,2,3,4-tetrahydroisoquinoline) sulphate

declinax

isocaramidinesulfate

RO 5-3307

RO 5-33071

2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-, sulfate (2:1)

DEBRISOQUINEHEMISULPHATE

3,4-Dihydro-2(1H)-isoquinolinecarboximidamide Hemisulfate

Debrisoquin Hemisulfate

Debrisoquine Hemisulfate

Isocaramidine Hemisulfate

3,4-dihydro-2(1h)-isoquinolinecarboxamidinesulfate

ebrisoquinsulfate

Debrisochinum

Debrisoquina

581-88-4

C10H13N32H2SO4

C20H26N6H2SO4

2C10H13N3H2O4S

C10H13N312H2SO4

Its metabolite may induce Parkinsonism.

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors by Enzyme

Enzyme Inhibitors

L to O

Monoamine oxidase competitive inhibitor

Biochemicals and Reagents

BioChemical

Bases & Related Reagents

Intermediates & Fine Chemicals

Nucleotides and Nucleosides

Nucleotides

Pharmaceuticals