AURANTIO-OBTUSIN

Product Name: AURANTIO-OBTUSIN
CAS No.: 67979-25-3
Chemical Name: AURANTIO-OBTUSIN
Synonyms: URANTIO-OBTUSIN;AURANTIO-OBTUSIN;Aurantio-obtusifolin;67979-25-3 AURANTIO-OBTUSIN;Aurantio-obtusin, 10 mM in DMSO;Aurantioobtusin, 98%, from Catsia tora Linn;1,3,7-Trihydroxy-2,8-dimethoxy-6-methylanthracene-9,10-dione;1,3,7-Trihydroxy-2,8-diMethoxy-6-Methyl-9,10-anthracenedione;9,10-Anthracenedione, 1,3,7-trihydroxy-2,8-dimethoxy-6-methyl-
CBNumber: CB61414271
Molecular Formula: C17H14O7
Formula Weight: 330.29
MOL File: 67979-25-3.mol

More

Less

AURANTIO-OBTUSIN Property

Melting point:: 265-266 °C
Boiling point:: 594.6±50.0 °C(Predicted)
Density: 1.510±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in chloroform, DMSO and methan
form: powder
pka: 6.32±0.20(Predicted)
color: Orange
InChI: InChI=1S/C17H14O7/c1-6-4-7-11(17(24-3)12(6)19)14(21)10-8(13(7)20)5-9(18)16(23-2)15(10)22/h4-5,18-19,22H,1-3H3
InChIKey: RNXZPKOEJUFJON-UHFFFAOYSA-N
SMILES: C1(O)=C2C(C(=O)C3=C(C2=O)C(OC)=C(O)C(C)=C3)=CC(O)=C1OC

More

Less

Safety

Safety Statements: 24/25
HS Code: 29389090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 27481
Product name: Aurantioobtusin
Packaging: 1mg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 27481
Product name: Aurantioobtusin
Packaging: 25mg
Price: $569
Updated: 2024/03/01

Cayman Chemical

Product number: 27481
Product name: Aurantioobtusin
Packaging: 5mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 27481
Product name: Aurantioobtusin
Packaging: 10mg
Price: $325
Updated: 2024/03/01

Usbiological

Product number: 299975
Product name: Aurantio-obtusin
Packaging: 20mg
Price: $390
Updated: 2021/12/16

More

Less

AURANTIO-OBTUSIN Chemical Properties,Usage,Production

Description

Aurantioobtusin is an anthraquinone originally isolated from Cassia seeds with diverse biological activities. It inhibits rat lens aldose reductase (RLAR) in vitro (IC₅₀ = 13.6 μM). Aurantioobtusin (10 and 100 μM) activates the aryl hydrocarbon receptor (AhR) in a concentration-dependent manner. It inhibits rat platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), ADP, and collagen. Aurantioobtusin induces vasorelaxation in isolated precontracted rat mesenteric artery rings, an effect that is inhibited by the PI3K inhibitor LY290042 or inhibition of endothelial nitric oxide synthase (eNOS). It is larvicidal against A. gambiae mosquitoes (LD₅₀ = 10 ppm).

Chemical Properties

Derived from the dried mature seeds of Cassia or Cassia minor, an annual herbaceous plant of the Leguminosae family

Uses

A compound found in herbal remedies, believed to have an effect on blood platelet aggregation and lower blood lipid count

Definition

ChEBI: A trihydroxyanthraquinone that is 1,3,7-trihydroxy-9,10-anthraquinone which is by methoxy groups at positions 2 and 8, and by a methyl group at position 6.

in vivo

Aurantio-obtusin (5-15 mg/kg; Oral administration; Single dose) in HFSW-induced mice reduces HFSW-induced lipid droplet accumulation and extensive steatosis in a dose-dependent manner^[3].
Aurantio-obtusin (5-15 mg/kg; Oral administration; A single dose) inhibits fatty acid synthesis, promotes FAO and activates AMPK signaling and autophagy in HFSW-induced mice ^[3].

Animal Model:	C57BL/6J mice model^[3]
Dosage:	5 mg/kg, 10 mg/kg, 15 mg/kg
Administration:	Oral gavage (p.o.), feeding with HFSW diet for 4 weeks then giving different dose of Aurantio-obtusin for another 4 weeks.
Result:	Decreased the levels of TG and TC in liver and TG, ALT and AST in serum induced by HSFW. Reduced the number and size of fat droplets in liver cells. Significantly increased AMPK phosphorylation in HFSW-induced mice.

References

[1] DAE SIK JANG. Anthraquinones from the seeds of Cassia tora with inhibitory activity on protein glycation and aldose reductase.[J]. Biological & pharmaceutical bulletin, 2007, 30 11: 2207-2210. DOI: 10.1248/bpb.30.2207
[2] YOSHIAKI AMAKURA. Characterization of natural aryl hydrocarbon receptor agonists from cassia seed and rosemary.[J]. Molecules, 2014, 19 4: 4956-4966. DOI: 10.3390/molecules19044956
[3] HYE SOOK YUN-CHOI Michio T Jae Hoon Kim. Potential Inhibitors of Platelet Aggregation from Plant Sources, V. Anthraquinones from Seeds of Cassia obtusifolia and Related Compounds[J]. Journal of Natural Products , 1990, 53 3: 630-633. DOI: 10.1021/np50069a014
[4] SHUZHEN LI . Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats[J]. Journal of pharmacological sciences, 2015, 128 3: Pages 108-115. DOI: 10.1016/j.jphs.2015.05.006
[5] VALENTINE C MBATCHOU. Mosquito larvicidal activity of Cassia tora seed extract and its key anthraquinones aurantio-obtusin and obtusin.[J]. Parasites & Vectors, 2017: 562. DOI: 10.1186/s13071-017-2512-y

AURANTIO-OBTUSIN Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

AURANTIO-OBTUSIN Suppliers

Canada 1 China 228 Germany 1 India 1 United Kingdom 1 United States 13 Global 245

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Fax: 086-28-85377358
Email: 2355253622@qq.com;
Country: China
ProdList: 1103
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

More

Less

View Lastest Price from AURANTIO-OBTUSIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Aurantio-obtusin 67979-25-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-03

Career Henan Chemical Co

Product: AURANTIO-OBTUSIN 67979-25-3
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000kg
Release date: 2018-08-10

67979-25-3, AURANTIO-OBTUSINRelated Search:

DanshenP.E Cabbage Extract/Cabbage PE. Aloe emodin Ferulic Acid Luteolin RADIX SCUTELLARIAE ASTRAGALUS P.E. DGL Salvia Root P.E Tanshinone IIA 20% Periplocoside Alkannin Cassia seed extract Indigo Hesperidin Esculetin Chrysoobtusin Brown pigment Cranesbill Extract

1,3,7-Trihydroxy-2,8-diMethoxy-6-Methyl-9,10-anthracenedione

Aurantio-obtusifolin

AURANTIO-OBTUSIN

1,3,7-Trihydroxy-2,8-dimethoxy-6-methylanthracene-9,10-dione

URANTIO-OBTUSIN

Aurantioobtusin, 98%, from Catsia tora Linn

9,10-Anthracenedione, 1,3,7-trihydroxy-2,8-dimethoxy-6-methyl-

67979-25-3 AURANTIO-OBTUSIN

Aurantio-obtusin, 10 mM in DMSO

67979-25-3

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Intermediates & Fine Chemicals

Pharmaceuticals