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SESELIN

Product Name
SESELIN
CAS No.
523-59-1
Chemical Name
SESELIN
Synonyms
Sesalin;Xie Hao Su;Seselin, 10 mM in DMSO;8,8-dimethylpyrano[2,3-h]chromen-2-one;8,8-dimethylpyrano[2,3-f]chromen-2-one;2,2-Dimethyl-1,5-dioxaphenanthrene-6(2H)-one;8,8-Dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one;8,8-Dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one;2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 8,8-dimethyl-
CBNumber
CB61444407
Molecular Formula
C14H12O3
Formula Weight
228.24
MOL File
523-59-1.mol
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SESELIN Property

Melting point:
119-124 °C
Boiling point:
403.0±45.0 °C(Predicted)
Density 
1.351 g/cm3(Temp: 18 °C)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29930
Product name
Seselin
Packaging
1mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
29930
Product name
Seselin
Packaging
5mg
Price
$456
Updated
2024/03/01
TRC
Product number
S280650
Product name
Seselin
Packaging
5mg
Price
$360
Updated
2021/12/16
TRC
Product number
S280650
Product name
Seselin
Packaging
10mg
Price
$685
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PXT0001956
Product name
SESELIN
Purity
95.00%
Packaging
5MG
Price
$496.49
Updated
2021/12/16
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SESELIN Chemical Properties,Usage,Production

Uses

Seselin is a coumarin compound that can be isolated from the root bark of the Citropsis articulata plant. Studies show that Seselin might exhibit potential antimalarial activity and that its derivatives may exhibit antithrombotic activity.

Definition

ChEBI: A natural product found in Citropsis articulata.

Biological Activity

Seselin is an anti-inflammatory, anti-parasitic and antifungal pyrancoumarin found in anise and other plants. It appears th at seselin targets Jak2 to block the proinflammatory phenotype of macrophages in models of sepsis. Seselin down-regulates levels of proinflammatory factors and activity of STAT1 and p65 in models of sepsis.

in vivo

Seselin (0.5-40.5 mg/kg; s.c.; once) shows peripheral anti-inflammatory and antinociceptive activities in mice[2].
Seselin (3-30 mg/kg; i.g.; once) ameliorates sepsis induced by caecal ligation and puncture in mice[3].

Animal Model:Male Swiss mice[2]
Dosage:0.5, 4.5 or 40.5 mg/kg
Administration:Subcutaneous injection; once
Result:Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.
Animal Model:C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model[3]
Dosage:3, 10 and 30 mg/kg
Administration:Intragastric administration, once
Result:Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.

SESELIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SESELIN Suppliers

China 60 United States 4 Global 64
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
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60
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
6905
Advantage
55
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Yihe Biological Technology Co., Ltd.
Tel
021-68882955 17721395025
Fax
021-68882955
Email
2423903095@qq.com
Country
China
ProdList
4991
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
028-028-85370565-229-229 18080489829
Email
18080489829@163.com
Country
China
ProdList
8250
Advantage
60
Henan Alfachem Co.,Ltd.
Tel
0371-55051623 18137891487
Fax
QQ：2853979817
Email
2853979817@qq.com
Country
China
ProdList
9988
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Nanjing Digger Medical Technology Co. Ltd.
Tel
025-025-51191215 18013836722
Fax
025-51191215
Email
2399235533@qq.com
Country
China
ProdList
4933
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58

523-59-1, SESELINRelated Search:

SESELIN ACETIC ACID 2-VINYLPHENYL ESTER 1,3-DIVINYLBENZENE 4-tert-Butoxystyrene Artemisinin

  • 2,2-Dimethyl-1,5-dioxaphenanthrene-6(2H)-one
  • 8,8-Dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one
  • 8,8-dimethylpyrano[2,3-h]chromen-2-one
  • 2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 8,8-dimethyl-
  • Sesalin
  • 8,8-dimethylpyrano[2,3-f]chromen-2-one
  • 8,8-Dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one
  • Seselin, 10 mM in DMSO
  • Xie Hao Su
  • 523-59-1
  • 523-29-1