TYROSINASE (206-214) (HUMAN)

Product Name: TYROSINASE (206-214) (HUMAN)
CAS No.: 166188-11-0
Chemical Name: TYROSINASE (206-214) (HUMAN)
Synonyms: L-Alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-L-arginyl-L-leucyl-L-phenylalanine;L-Phenylalanine, L-alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-L-arginyl-L-leucyl-;(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
CBNumber: CB61477614
Molecular Formula: C61H83N15O10
Formula Weight: 1186.41
MOL File: 166188-11-0.mol

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TYROSINASE (206-214) (HUMAN) Property

Density: 1.38±0.1 g/cm3(Predicted)
pka: 3.50±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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TYROSINASE (206-214) (HUMAN) Chemical Properties,Usage,Production

Uses

Tyrosinase (206-214), human (AFLPWHRLF), a 9-amino acid peptide, is a tyrosinase epitope. Tyrosinase (206-214), human can be recognized by HLA-A24 restricted, tumor-infiltrating lymphocytes (TIL)[1].

in vivo

Tyrosinase (206-214) is administered intranasally (i.n.; 45 μL; weekly for three weeks) into HLA-A24 transgenic (A24Tg) mice. Tyrosinase (206-214) shows an accumulation of murine CD3⁺ and CD8⁺ cells around the bronchioles. All A24Tg immunized with Tyrosinase (206-214) died after lethal A/HK483 infection^[2].

References

[1] X Kang, et al. Identification of a tyrosinase epitope recognized by HLA-A24-restricted, tumor-infiltrating lymphocytes. J Immunol. 1995 Aug 1;155(3):1343-8. PMID:7543520
[2] Toru Ichihashi, et al. Cross-protective peptide vaccine against influenza A viruses developed in HLA-A*2402 human immunity model. PLoS One. 2011;6(9):e24626. DOI:10.1371/journal.pone.0024626

TYROSINASE (206-214) (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

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166188-11-0, TYROSINASE (206-214) (HUMAN)Related Search:

H-SER-GLU-ILE-TRP-ARG-ASP-ILE-ASP-PHE-OH H-LYS-CYS-ASP-ILE-CYS-THR-ASP-GLU-TYR-OH (ASP371)-TYROSINASE (369-377) (HUMAN)

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid

L-Phenylalanine, L-alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-L-arginyl-L-leucyl-

L-Alanyl-L-phenylalanyl-L-leucyl-L-prolyl-L-tryptophyl-L-histidyl-L-arginyl-L-leucyl-L-phenylalanine

166188-11-0

C61H83N15O10