N-Bromoacetyl--alanine
- Product Name
- N-Bromoacetyl--alanine
- CAS No.
- 89520-11-6
- Chemical Name
- N-Bromoacetyl--alanine
- Synonyms
- N-Bromoacetyl--alanine;N-Bromoacetyl-2-alanine;N-Bromoacetyl-β-alanine;N-Bromoacetyl-Beta-Alanine;β-Alanine, N-(2-bromoacetyl)-;(S)-2-(2-bromoacetamido)propanoic acid
- CBNumber
- CB61873364
- Molecular Formula
- C5H8BrNO3
- Formula Weight
- 210.03
- MOL File
- 89520-11-6.mol
N-Bromoacetyl--alanine Property
- Melting point:
- 71-77°C
- Boiling point:
- 433.4±30.0 °C(Predicted)
- Density
- 1.682±0.06 g/cm3(Predicted)
- solubility
- Dichloromethane
- form
- Pale Yellow Semi-Solid
- pka
- 4.27±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- B679080
- Product name
- N-Bromoacetyl-β-alanine
- Packaging
- 2.5g
- Price
- $1230
- Updated
- 2021/12/16
- Product number
- AAA0004880
- Product name
- N-BROMOACETYL-BETA-ALANINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1420.65
- Updated
- 2021/12/16
- Product number
- AAA0004880
- Product name
- N-BROMOACETYL-BETA-ALANINE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1947
- Updated
- 2021/12/16
- Product number
- BP-21092
- Product name
- 3-(2-bromoacetamido)propanoicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $850
- Updated
- 2021/12/16
- Product number
- 4158-9-04
- Product name
- 3-(2-Bromoacetamido)propanoic acid
- Packaging
- 250mg
- Price
- $877
- Updated
- 2021/12/16
N-Bromoacetyl--alanine Chemical Properties,Usage,Production
Description
3-(2-bromoacetamido)propanoic acid is a compound containing a bromide group and a terminal carboxylic acid. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties
Pale Yellow Semi-Solid
Uses
N-Bromoacetyl-β-alanine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-Bromoacetyl-β-alanine is also a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
IC 50
Alkyl-Chain; Cleavable Linker
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
[2] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
N-Bromoacetyl--alanine Preparation Products And Raw materials
Raw materials
Preparation Products
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