ChemicalBook > CAS DataBase List > 4-Hydroxy-2-methylpyridine

4-Hydroxy-2-methylpyridine

Product Name
4-Hydroxy-2-methylpyridine
CAS No.
18615-86-6
Chemical Name
4-Hydroxy-2-methylpyridine
Synonyms
2-METHYL-PYRIDIN-4-OL;4-Pyridinol, 2-methyl-;2-Methylpyridin-4-ol 98%;4-HYDROXY-2-METHYLPYRIDINE;2-Methyl-4-hydroxy-pyridin;2-Methyl-4-hydroxypyridine;4-Hydroxy-2-methylpyridine ,97%;4-Hydroxy-2-methylpyridine nitrate;4-Hydroxy-2-methylpyridine ISO 9001：2015 REACH
CBNumber
CB6189396
Molecular Formula
C6H7NO
Formula Weight
109.13
MOL File
18615-86-6.mol
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4-Hydroxy-2-methylpyridine Property

Melting point:
174-176 °C(Solv: acetone (67-64-1))
Boiling point:
350-360 °C
Density 
1.120±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
5.36±0.18(Predicted)
Appearance
White to light yellow Solid
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25-36/37/39
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
M312885
Product name
2-Methyl-4-hydroxypyridine
Packaging
10g
Price
$745
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
60136
Product name
2-Methyl-4-hydroxypyridine
Packaging
1g
Price
$610
Updated
2021/12/16
Oakwood
Product number
076527
Product name
4-Hydroxy-2-methylpyridine
Purity
98%
Packaging
250mg
Price
$21
Updated
2021/12/16
Matrix Scientific
Product number
072752
Product name
4-Hydroxy-2-methylpyridine
Purity
95+%
Packaging
1g
Price
$42
Updated
2021/12/16
ChemScene
Product number
CS-W018581
Product name
2-Methylpyridin-4-ol
Purity
99.97%
Packaging
5g
Price
$51
Updated
2021/12/16
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4-Hydroxy-2-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

2-Methyl-4-hydroxypyridine is used in the synthesis of novel indolizine compounds as inhibitors of phosphodiesterase IV. Also used in the preparation of 2-substituted imidazole ring compoiunds for treatment againast human African trypanosomiasis.

Synthesis

18437-58-6

18615-86-6

General procedure for the synthesis of 4-hydroxy-2-methylpyridine from 2-methyl-4-aminopyridine: [0220] To an aqueous solution (75 mL) containing 2-methylpyridin-4-amine (10.2 g, 94 mmol) and nitric acid (56.5 mL, 1,273 mmol) was slowly added a solution of sodium nitrite solution (9.44 g, 137 mmol) in water (38 mL) over a period of 25 minutes at 0 °C while maintaining vigorous stirring. The reaction mixture was continued to be stirred at 0 °C for 30 min, followed by transfer to a refrigerator at -17 °C for overnight storage. Upon completion of the reaction, the mixture was filtered and the solid product was collected and dried under vacuum to afford 2-methylpyridin-4-ol (6.5 g, 59.6 mmol, 63.2% yield) as a beige solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 2.53-2.60 (m, 3H), 7.01-7.17 (m, 2H), 8.36-8.49 (m, 1H). Mass spectrometry analysis showed a measured value of 110.1 for [M + H]+.

References

[1] Patent: WO2011/146287, 2011, A1. Location in patent: Page/Page column 59
[2] Archiv der Pharmazie (Weinheim, Germany), 1958, vol. 291, p. 429,434
[3] Roczniki Chemii, 1957, vol. 31, p. 1147,1151
[4] Chem.Abstr., 1958, p. 10072
[5] Journal of Chemical Thermodynamics, 1982, vol. 14, # 1, p. 45 - 50

4-Hydroxy-2-methylpyridine Preparation Products And Raw materials

Raw materials

Ethanol Potassium carbonate Chloroform Sodium nitrite Ethyl acetate Hydrochloric acid 4-Nitro-2-picoline N-oxide Dichloromethane Acetic acid Sodium hydroxide Iron Sulfuric acid

Preparation Products

6-CHLORO-4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID
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4-Hydroxy-2-methylpyridine Suppliers

China 135 Germany 2 India 3 United Kingdom 2 United States 18 Global 160
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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HBCChem, Inc.
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+1-650-486-1361
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Accela ChemBio Inc.
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+1(858) 699-3322
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+1(858) 876-1948
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AbaChemScene
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732-484-9848
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Alchem Pharmtech,Inc.
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Aladdin Scientific
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SynQuest Laboratories, Inc.
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Frontier Scientific, Inc.
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Matrix Scientific
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Sphinx Scientific Laboratory, LLC
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Lianyungang Ziyan Chemical Co., Ltd.
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Wilshire Chemical Company Inc.
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AlliChem, LLC
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3B Scientific Corporation
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APAC Pharmaceutical, LLC
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ChemPacific Corporation
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View Lastest Price from 4-Hydroxy-2-methylpyridine manufacturers

Dideu Industries Group Limited
Product
4-Hydroxy-2-methylpyridine 18615-86-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-24
Career Henan Chemical Co
Product
4-Hydroxy-2-methylpyridine 18615-86-6
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

18615-86-6, 4-Hydroxy-2-methylpyridineRelated Search:

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  • 2-Methyl-4-hydroxy-pyridin
  • 4-HYDROXY-2-METHYLPYRIDINE
  • 2-METHYL-PYRIDIN-4-OL
  • 2-Methyl-4-hydroxypyridine
  • 4-Hydroxy-2-methylpyridine ,97%
  • 4-Hydroxy-2-methylpyridine nitrate
  • 2-Methylpyridin-4-ol 98%
  • 4-Pyridinol, 2-methyl-
  • 4-Hydroxy-2-methylpyridine ISO 9001：2015 REACH
  • 18615-86-6
  • Pyridines
  • Heterocyclic Series