2-Ethoxybenzonitrile
- Product Name
- 2-Ethoxybenzonitrile
- CAS No.
- 6609-57-0
- Chemical Name
- 2-Ethoxybenzonitrile
- Synonyms
- Ethoxybenzonitril;O-ETHOXYBENZONITRILE;2-ETHOXYBENZONITRILE;2-Ethoxybenzonitrile>Benzonitrile, 2-ethoxy-;O-ETHOXYBENZONITRILE 95%;2-ETHOXYBENZONITRILE 98%;2-Ethoxybenzonitrile o-Ethoxybenzonitrile
- CBNumber
- CB6205010
- Molecular Formula
- C9H9NO
- Formula Weight
- 147.17
- MOL File
- 6609-57-0.mol
2-Ethoxybenzonitrile Property
- Melting point:
- 5°C(lit.)
- Boiling point:
- 154°C 20mm
- Density
- 1.053 g/mL at 25 °C (lit.)
- vapor pressure
- 0.49-54000Pa at 20-238℃
- refractive index
- n20/D 1.5322(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- Liquid
- color
- Clear colorless to pale yellow
- LogP
- 2.6 at 25℃ and pH6.6
- Surface tension
- 54.5mN/m at 511.2mg/L and 20.1℃
- CAS DataBase Reference
- 6609-57-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-37/39
- RIDADR
- UN3276
- WGK Germany
- 2
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29269095
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 283576
- Product name
- 2-Ethoxybenzonitrile
- Purity
- 98%
- Packaging
- 1g
- Price
- $93.6
- Updated
- 2023/01/07
- Product number
- E0968
- Product name
- 2-Ethoxybenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2025/07/31
- Product number
- E0968
- Product name
- 2-Ethoxybenzonitrile
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $107
- Updated
- 2025/07/31
- Product number
- E891333
- Product name
- 2-Ethoxybenzonitrile
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 003296
- Product name
- 2-Ethoxybenzonitrile
- Purity
- 98%
- Packaging
- 25g
- Price
- $53
- Updated
- 2021/12/16
2-Ethoxybenzonitrile Chemical Properties,Usage,Production
Uses
2-Ethoxybenzonitrile has been used in the synthesis of selective phosphodiesterase(V) inhibitor, vardenafil.
Synthesis
64-67-5
611-20-1
6609-57-0
To a 250 mL three-necked flask was added 5.95 g (0.05 mol) of o-hydroxybenzonitrile, 20 mL of 10% aqueous NaOH and 80 mL of toluene and the mixture was heated to 70 °C and maintained at this temperature for 1 hour of reaction. Subsequently, the temperature was lowered to 60 °C and 9.24 g of diethyl sulfate was slowly added dropwise. After the dropwise addition, the reaction temperature was raised to 70 °C and the reaction was continued for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) until o-hydroxybenzonitrile completely disappeared. After completion of the reaction, the mixture was cooled to room temperature and liquid-liquid separation was carried out. The toluene layer was collected and the solvent was removed by evaporation to give a light yellow oily liquid 2-ethoxybenzonitrile 6.98 g in 95% yield.
References
[1] Patent: CN108440519, 2018, A. Location in patent: Paragraph 0021; 0022; 0023; 0024
[2] Patent: CN108341808, 2018, A. Location in patent: Paragraph 0021; 0022; 0023
2-Ethoxybenzonitrile Preparation Products And Raw materials
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View Lastest Price from 2-Ethoxybenzonitrile manufacturers
- Product
- 2-Ethoxybenzonitrile 6609-57-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-07