ChemicalBook > CAS DataBase List > GGSTOPTM
GGSTOPTM
- Product Name
- GGSTOPTM
- CAS No.
- 926281-37-0
- Chemical Name
- GGSTOPTM
- Synonyms
- GGsTop;GGSTOPTM;GGsTop(R);GGsTop (Nahlsgen);GGsTop (Synonyms: Nahlsgen);3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid;2-Amino-4-((3-(carboxymethyl)phenoxy)(methoxy)phosphoryl)butanoic acid;Benzeneacetic acid, 3-[[(3-amino-3-carboxypropyl)methoxyphosphinyl]oxy]-
- CBNumber
- CB62467186
- Molecular Formula
- C13H18NO7P
- Formula Weight
- 331.26
- MOL File
- 926281-37-0.mol
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GGSTOPTM Property
- Boiling point:
- 557.7±50.0 °C(Predicted)
- Density
- 1.403±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- <33.13mg/ml in H2O; <33.13mg/ml in DMSO
- form
- solid
- pka
- 2.18±0.10(Predicted)
- color
- White
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N-Bromosuccinimide Price
Tocris
- Product number
- 4452
- Product name
- GGsTop
- Purity
- ≥95%(HPLC)
- Packaging
- 10
- Price
- $235
- Updated
- 2021/12/16
TRC
- Product number
- N497063
- Product name
- Nahlsgen
- Packaging
- 10mg
- Price
- $160
- Updated
- 2021/12/16
Usbiological
- Product number
- 255372
- Product name
- GGsTop
- Packaging
- 10mg
- Price
- $522
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B5602
- Product name
- GGsTop
- Packaging
- 10mg
- Price
- $345
- Updated
- 2021/12/16
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GGSTOPTM Chemical Properties,Usage,Production
Uses
Nahlsgen is a highly selective, and irreversible γ-?glutamyl transpeptidase (GGT) inhibitor with no inhibitory activity on glutamine amidotransferases.
in vivo
GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats[3].
GGsTop also reduces 4-HNE and TNF-α production, and decreases hepatic necrosis in rats[3].
| Animal Model: | Male rats (9 week old)[3] |
| Dosage: | 1 mg/kg |
| Administration: | Injected into the inferior vena cava for 12, 24, 48 h |
| Result: | Lowered the serum levels of ALT, AST, prevented the increase of serum γ-GT levels in IR-GGsTop group. |
storage
Store at -20°C
GGSTOPTM Preparation Products And Raw materials
Raw materials
Preparation Products
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