EGFR/ErbB-2 Inhibitor

Product Name: EGFR/ErbB-2 Inhibitor
CAS No.: 179248-61-4
Chemical Name: EGFR/ErbB-2 Inhibitor
Synonyms: ErbB2 inhibitor;EGFR/ErbB-2 Inhibitor;EGFR/ErbB-2/ErbB-4 inhibitor-2;EGFR/ErbB-2/ErbB-4 inhibitor-2, 10 mM in DMSO;N-(4-(Benzyloxy)phenyl)-6,7-dimethoxyquinazolin-4-amine;6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine;6,7-Dimethoxy-N-[4-(phenylmethoxy)phenyl]-4-quinazolinamine;4-Quinazolinamine, 6,7-dimethoxy-N-[4-(phenylmethoxy)phenyl]-;EGFR/ErbB2/ErbB4 inhibitor2,EGFR,HER1,Inhibitor,inhibit,ErbB2,HN5,Epidermal growth factor receptor,EGFR/ErbB 2/ErbB 4 inhibitor 2,ErbB4,ErbB-1
CBNumber: CB62501842
Molecular Formula: C23H21N3O3
Formula Weight: 387.43
MOL File: 179248-61-4.mol

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EGFR/ErbB-2 Inhibitor Property

Boiling point:: 560.6±50.0 °C(Predicted)
Density: 1.254±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: ≤1mg/ml in DMSO;10mg/ml in dimethyl formamide
form: crystalline solid
pka: 5.58±0.30(Predicted)
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17568
Product name: EGFR/ErbB2 Inhibitor
Purity: ≥95%
Packaging: 1mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 17568
Product name: EGFR/ErbB2 Inhibitor
Purity: ≥95%
Packaging: 5mg
Price: $477
Updated: 2024/03/01

ApexBio Technology

Product number: C3285
Product name: EGFR/ErbB2Inhibitor
Packaging: 5mg
Price: $543
Updated: 2021/12/16

ApexBio Technology

Product number: C3285
Product name: EGFR/ErbB2Inhibitor
Packaging: 1mg
Price: $137
Updated: 2021/12/16

AK Scientific

Product number: 3569CR
Product name: EGFR/ErbB-2Inhibitor
Packaging: 1mg
Price: $232
Updated: 2021/12/16

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EGFR/ErbB-2 Inhibitor Chemical Properties,Usage,Production

Uses

6,7-Dimethoxy-N-[4-(phenylmethoxy)phenyl]-4-quinazolinamine is a cell-permeable inhibitor of EFGR and c-ErbB2. This drug inhibits the proliferation of cancer cells.

Biological Activity

egfr/erbb2 inhibitor is an egfr and c-erbb2 inhibitor.egfr and c-erbb-2 are members of the epidermal growth factor receptor subfamily of protein tyrosine kinases. their cellular overexpression causes transformation, so that the cells will grow in the absence of growth factors. an inhibitor of thse kinases should block the receptor signalling, subsequent transformation and inappropriate growth.

in vitro

egfr/erbb2 inhibitor was identified as a potent inhibitor of both c-erbb-2 and egfr [ic50: 0.079 μm for c-erbb-2, 0.020 μm for egfr (isolated enzyme), 2.0 μm for hb4ac5.2 cells, 1.2 μm for bt474, both overexpressing c-erbb-2; 2.5 μm for hn5 cells overexpressing egfr]. this combined potency was contrast to smaller, previously reported anilinoquinazolines and its subsequent analogues [1].

in vivo

gw974, a analog of egfr/erbb2 inhibitor, was evaluated in the fast growing n87 gastric tumour xenograft in scid mice. results showed that gw974 at bid dose of 10 mg/kg po led to a 50% inhibition of tumour growth over the 20-day dosing period. moreover, gw974 at 10 mg/kg po bid had complete inhibition of tumour growth over the 20-day dosing period in the bt474 breast tumour xenograft model. a longer-term study with initial dosing at 30 mg/kg po bid produced tumour shrinkage [1].

IC 50

20 and 79 nm for egfr and c-erbb2, respectively

References

[1] s. cockerill, c. stubberfield, j. stables, et al. indazolylamino quinazolines and pyridopyrimidines as inhibitors of the egfr and c-erbb-2. bioorganic & medicinal chemistry letters 11, 1401-1405 (2001).

EGFR/ErbB-2 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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179248-61-4, EGFR/ErbB-2 InhibitorRelated Search:

EGFR/ErbB-2 Inhibitor

6,7-dimethoxy-N-(4-phenylmethoxyphenyl)quinazolin-4-amine

6,7-Dimethoxy-N-[4-(phenylmethoxy)phenyl]-4-quinazolinamine

ErbB2 inhibitor

EGFR/ErbB-2/ErbB-4 inhibitor-2

EGFR/ErbB2/ErbB4 inhibitor2,EGFR,HER1,Inhibitor,inhibit,ErbB2,HN5,Epidermal growth factor receptor,EGFR/ErbB 2/ErbB 4 inhibitor 2,ErbB4,ErbB-1

4-Quinazolinamine, 6,7-dimethoxy-N-[4-(phenylmethoxy)phenyl]-

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EGFR/ErbB-2/ErbB-4 inhibitor-2, 10 mM in DMSO

179248-61-4

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