BD 1008 Dihydrobromide
- Product Name
- BD 1008 Dihydrobromide
- CAS No.
- 138356-09-9
- Chemical Name
- BD 1008 Dihydrobromide
- Synonyms
- BD-1008 HBr;BD 1008 (hydrobromide);BD 1008 dihydrobromide, 10 mM in DMSO;BD 1008 dihydrobromide, delta1-receptor antagonist;N-[2-(3,4-Dichlorophenyl)ethyl]-N-Methyl-1-pyrrolidineethanaMine DihydrobroMide;1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-, hydrobromide (1:2)
- CBNumber
- CB62503053
- Molecular Formula
- C15H22Cl2N2
- Formula Weight
- 301.25458
- MOL File
- 138356-09-9.mol
BD 1008 Dihydrobromide Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in H2O
- form
- solid
- color
- White to off-white
- Water Solubility
- Soluble to 50 mM in water
N-Bromosuccinimide Price
- Product number
- 9001336
- Product name
- BD 1008 (hydrobromide)
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 9001336
- Product name
- BD 1008 (hydrobromide)
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $74
- Updated
- 2024/03/01
- Product number
- 9001336
- Product name
- BD 1008 (hydrobromide)
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- 9001336
- Product name
- BD 1008 (hydrobromide)
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $547
- Updated
- 2024/03/01
- Product number
- B129450
- Product name
- BD1008Dihydrobromide
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
BD 1008 Dihydrobromide Chemical Properties,Usage,Production
Uses
An α receptor antagonist, attenuating the biochemical effects of cocaine. Also studied was this compounds ability to prevent neuropathic pain following chemotherapy.
Biological Activity
bd 1008 dihydrobromide is a potent and selective ligand for σ-receptor with ki values of 2 and 8 nm for σ-1 receptor and σ-2 receptor, respectively [1].σ-receptor is a type of opioid receptor. there are two subtypes of σ-receptor: σ-1 and σ-2 [2].bd 1008 dihydrobromide is a potent and selective σ-receptor ligand. bd1008 showed high affinity to sites labeled by 4-[125i]pemp with ki value of 5.06 nm in guinea pig brain membranes. in mcf-7 breast cancer and melanoma (a375) cells, 4-[125i]pemp inhibited the binding of bd1008 with ki value of 11 nm in a dose-dependent way [2]. in xenopus oocytes coexpressed n-methyl-d-aspartate (nmda) receptor (nr) 1a with either nr2a, 2b or 2c, bd1008 inhibited nmda-activated membrane current responses with ic50 values of 62, 18 and 120 μm for nr1a/2a, nr1a/2b and nr1a/2c respectively, which were due to direct effects on the receptor channel complex [3].in mice, bd1008 (1 mg/kg) inhibited cocaine-induced locomotor activity with ed50 value increased from 6.50 mg/kg to 11.19 mg/kg [1].
References
[1]. mccracken ka, bowen wd, matsumoto rr. novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine. eur j pharmacol, 1999, 365(1): 35-38.
[2]. john cs, gulden me, vilner bj, et al. synthesis, in vitro validation and in vivo pharmacokinetics of [125i]n-[2-(4-iodophenyl)ethyl]-n-methyl-2-(1-piperidinyl) ethylamine: a high-affinity ligand for imaging sigma receptor positive tumors. nucl med biol, 1996, 23(6): 761-766.
[3]. whittemore er, ilyin vi, woodward rm. antagonism of n-methyl-d-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. j pharmacol exp ther, 1997, 282(1): 326-338.
BD 1008 Dihydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
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