Farnesyl Pyrophosphate Triammonium Salt

Farnesyl Pyrophosphate Triammonium Salt Property

storage temp. 

Amber Vial, -20°C Freezer, Under Inert Atmosphere

solubility 

Methanol:NH4OH (70:30): * 1 mg/ml

form 

Solid

color 

White to Brown

Stability:

Hygroscopic, Light Sensitive, Temperature Sensitive

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H370Causes damage to organs

H400Very toxic to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P307+P311IF exposed: call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P370+P378In case of fire: Use … for extinction.

P391Collect spillage. Hazardous to the aquatic environment

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

Farnesyl Pyrophosphate Triammonium Salt Chemical Properties,Usage,Production

Description

Farnesyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway and used in the biosynthesis of terpenes, terpenoids, and sterols. It also serves as a donor in post-translational isoprenylation of proteins. FPP has been identified as an antagonist of P2Y₁₂ receptors (IC₅₀ = 45 μM), attenuating platelet aggregation. It has also been shown to regulate adipocyte function as an endogenous PPARγ agonist. Additionally, because of a flexible hydrocarbon chain that enables different conformations, FPP is a promiscuous ligand for a subset of nuclear receptors.

Chemical Properties

Pale Yellow Low Melting Solid

Uses

Isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.

Uses

Isoprenoid from the intracellular mevalonate pathway, Farnesyl Pyrophosphate Triammonium Salt can be used for prenylation of several low molecular mass G proteins, including Ras.

References

[1] MCTAGGART S J. Isoprenylated proteins.[J]. Cellular and Molecular Life Sciences, 2006, 63 3: 255-267. DOI: 10.1007/s00018-005-5298-6
[2] CARL H?GBERG. Farnesyl pyrophosphate is an endogenous antagonist to ADP-stimulated P2Y?? receptor-mediated platelet aggregation.[J]. Thrombosis and haemostasis, 2012, 108 1: 119-132. DOI: 10.1160/th11-10-0749
[3] TSUYOSHI GOTO. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist.[J]. Biochemical Journal, 2011: 111-119. DOI: 10.1042/bj20101939
[4] RITU GOYANKA. Nuclear receptor engineering based on novel structure activity relationships revealed by farnesyl pyrophosphate.[J]. Protein Engineering Design & Selection, 2010, 23 11: 809-815. DOI: 10.1093/protein/gzq056