ChemicalBook > CAS DataBase List > 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide

Product Name
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
CAS No.
511296-88-1
Chemical Name
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
Synonyms
PFT-β;CS-1771;HY-16702A;Pifithrin B;Pifithrin-β;Cyclic PFT-α;Cyclic PFT-α;Pifithrin-beta;Cyclic Pifithrin-α;Pifithrin-β(PPT-β)
CBNumber
CB62518925
Molecular Formula
C16H16N2S.HBr
Formula Weight
349
MOL File
511296-88-1.mol
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5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Property

storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL
form 
powder to crystal
color 
White to Almost white
Merck 
14,7421
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Safety

WGK Germany 
3
HS Code 
2934.99.4400
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P4236
Product name
Cyclic Pifithrin-α hydrobromide
Purity
≥98% (HPLC)
Packaging
5mg
Price
$200
Updated
2024/03/01
Sigma-Aldrich
Product number
P4236
Product name
Cyclic Pifithrin-α hydrobromide
Purity
≥98% (HPLC)
Packaging
10mg
Price
$336
Updated
2024/03/01
TCI Chemical
Product number
C2826
Product name
Cyclic Pifithrin-alpha Hydrobromide
Purity
>98.0%(HPLC)
Packaging
20mg
Price
$336
Updated
2023/01/07
TCI Chemical
Product number
C2826
Product name
Cyclic Pifithrin-alpha Hydrobromide
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$805
Updated
2024/03/01
Cayman Chemical
Product number
14748
Product name
Cyclic Pifithrin-α (hydrobromide)
Purity
≥95%
Packaging
5mg
Price
$57
Updated
2024/03/01
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5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Chemical Properties,Usage,Production

Description

Pifithrin-α (PFT-α; ) is a reversible inhibitor of p53-dependent transcription and apoptosis. Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 μM, respectively). At doses lower than those that inhibit growth, cyclic PFT-α induces autophagy in HCT116 cells and sensitizes IGROV-1 and H460 cells to anti-microtubule agents. In addition, 10 μM cyclic PFT-α blocks p53-dependent protection from DNA damage, induced by hydrogen peroxide or ultraviolet radiation, in melanocytes.

Uses

Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke?induced apoptosis of pulmonary endothelial cells.

Biochem/physiol Actions

A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.

in vitro

pifithrin-α blocks p53-dependent transactivation of p53-responsive genes in cona cells. pifithrin-α (10 μm) inhibits apoptotic death of c8 cells guided by etoposide, taxol, dox, cytosine arabinoside. pifithrin-α has significant effect on the inhibition of p53-dependent growth arrest of human diploid fibroblasts in response to dna damage but not on p53-deficient fibroblasts. pifithrin-α may monitor the nuclear import or export (or both) of p53 or may make nuclear p53 instability [2].

in vivo

pifithrin-α-mice (2.2 mg/kg i.p.) were completely survival with both strains from 60% killing doses of gamma irradiation (8 gy for c57bl and 6 gy for balb/c). mice pretreated with pfithrin-α lost less weight than irradiated mice without the pifithrin-α. pifithrin-α (2.2 mg/kg) eliminates p53-dependent regulation of dna replication after whole-body gamma irradiation in mice [2].

storage

Desiccate at RT

References

[1] komarova ea and gudkov a v. could p53 be a target for therapeutic suppression semin. cancer biol. 1998, 8: 389-400.
[2] komarov pg, komarova ea, kondratov rv, christov-tselkov k, coon js, chernov mv, gudkov av. a chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. science. 1999 sep 10; 285(5434):1733-7.

5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

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5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Suppliers

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AdooQ BioScience, LLC
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View Lastest Price from 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide manufacturers

Career Henan Chemical Co
Product
5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide 511296-88-1
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

511296-88-1, 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromideRelated Search:

2-(3,4-DICHLOROPHENYL)-N-METHYL-N-[(1S)-1-PHENYL-2-(1-PYRROLIDINYL)ETHYL]ACETAMIDE HYDROCHLORIDE Citalopram hydrobromide Ascorbic Acid

  • 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide
  • Cyclic Pifithrin-α HBr
  • Pifithrin- beta hydrobromide
  • Cyclic PFT-α
  • Pifithrin B
  • PIFITHRIN-Β;PIFITHRIN B;CYCLIC PFT-Α; PIFITHRIN-Β; PFT-Β
  • CS-1771
  • CYCLIC PIFITHRIN-Α HYDROBROMIDE;CYCLIC PFT-Α HYDROBROMIDE;PFT-Β HYDROBROMIDE
  • Cyclic Pifithrin-α hydrobromide
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  • Cyclic Pifithrin-alpha HydrobroMide
  • 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazolehydrobromide Pifithrin-β
  • 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide
  • Cyclic PFT-α hydrobromide
  • Pifithrin-α, cyclic
  • HY-16702A
  • Cyclic Pifithrin-α Hydrobromide &gt
  • Pifithrin-β
  • Pifithrin-β hydrobromide
  • Cyclic Pifithrin-α
  • 2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide
  • Pifithrin-α, Cyclic, hydrobromide
  • Pifithrin-β HBr (QB102
  • Cyclic Pifithrin-α Hydrobromide
  • Cyclic PFT-α
  • PFT β (hydrobromide)
  • PFT-β
  • 2-(p-Tolyl)-5,6,7,8-tetrahydrobenzo[d]imidazo[2,1-b]thiazole hydrobromide
  • Imidazo[2,1-b]benzothiazole, 5,6,7,8-tetrahydro-2-(4-methylphenyl)-, hydrobromide (1:1)
  • 5,6,7,8-tetrahydro-2-(4-methylphenyl)-Imidazo[2,1-b]benzothiazole hydrobromide (1:1)
  • inhibit,MDM-2/p53,Pifithrinβ hydrobromide,Ferroptosis,Pifithrin β hydrobromide,Cyclic Pifithrin-α,Inhibitor,PFT β
  • Pifithrin-β(PPT-β)
  • 511296-88-1
  • C16H16N2SHBr
  • C16H16N2SBrH