1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione

Product Name: 1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione
CAS No.: 878533-35-8
Chemical Name: 1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione
Synonyms: CAY10508;1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione;2,4-Imidazolidinedione, 1,3-bis(4-bromophenyl)-5-phenyl-
CBNumber: CB62520816
Molecular Formula: C21H14Br2N2O2
Formula Weight: 486.16
MOL File: 878533-35-8.mol

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1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione Property

solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:2): .25 mg/ml; DMSO: 10 mg/ml
form: Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10008669
Product name: CAY10508
Purity: ≥98%
Packaging: 5mg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 10008669
Product name: CAY10508
Purity: ≥98%
Packaging: 10mg
Price: $50
Updated: 2024/03/01

Cayman Chemical

Product number: 10008669
Product name: CAY10508
Purity: ≥98%
Packaging: 25mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 10008669
Product name: CAY10508
Purity: ≥98%
Packaging: 50mg
Price: $207
Updated: 2024/03/01

TRC

Product number: B414805
Product name: 1,3-Bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione
Packaging: 50mg
Price: $165
Updated: 2021/12/16

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1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione Chemical Properties,Usage,Production

Description

Central cannabinoid (CB₁) receptor antagonists and inverse agonists exhibit therapeutic potential for obesity and drug dependence, while being devoid of psychotropic effects. CAY10508 is a potent and selective central cannabinoid (CB₁) receptor inverse agonist with a K_i value of 243 nM and an EC₅₀ of 195 nM. A 10 μM concentration of CAY10508 resulted in 100% and 35% displacement of [³H]-CP-55,940 at the CB₁ and peripheral cannabinoid (CB₂) receptors, respectively. A [35S]-GTPγS binding assay revealed the inverse agonist properties of CAY10508 at the CB₁ receptor.

Uses

1,3-Bis(4-bromophenyl)-5-phenyl-2,4-imidazolidinedione is a central cannabinoid (CB1) receptor antagonist and inverse agonist. It may be a potential therapeutic agent for treating obesity and drug dependence.

Uses

An imidazolidine-2,-4-dione derivative that is an effective and selective inverse agonist of CB cannabinoid receptor

IC 50

hCB₁: 195 nM (EC₅₀); hCB₁: 243 nM (Ki)

References

[1] GIULIO G. MUCCIOLI. Synthesis and Activity of 1,3,5-Triphenylimidazolidine-2,4-diones and 1,3,5-Triphenyl-2-thioxoimidazolidin-4-ones: Characterization of New CB1 Cannabinoid Receptor Inverse Agonists/Antagonists[J]. Journal of Medicinal Chemistry, 2006, 49 3: 872-882. DOI: 10.1021/jm050484f

1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione Suppliers

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878533-35-8, 1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedioneRelated Search:

1,3-bis(4-Bromophenyl)-5-phenyl-2,4-imidazolidinedione

CAY10508

2,4-Imidazolidinedione, 1,3-bis(4-bromophenyl)-5-phenyl-

878533-35-8

Cannabinoids.