PTP Inhibitor IV

Product Name: PTP Inhibitor IV
CAS No.: 329317-98-8
Chemical Name: PTP Inhibitor IV
Synonyms: PTP Inhibitor IV;PTP Inhibitor IV, 10 mM in DMSO;-[1,4-Phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1]-trifluoro-methanesulfonamide;N,N'-[1,4-Phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1]-trifluoro-methanesulfonamide;N,N'-((1,4-Phenylenebis(propane-2,2-diyl))bis(4,1-phenylene))bis(1,1,1-trifluoromethanesulfonamide);N,N'-((1,4-Phenylenebis(propane-2,2-diyl))bis(4,1-phenylene))bis(1,1,1-trifluoromethanesulfonamide);Methanesulfonamide, N,N'-[1,4-phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1-trifluoro-
CBNumber: CB62520821
Molecular Formula: C26H26F6N2O4S2
Formula Weight: 608.616
MOL File: 329317-98-8.mol

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PTP Inhibitor IV Property

Boiling point:: 578.0±60.0 °C(Predicted)
Density: 1.416±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≤25mg/ml in ethanol;25mg/ml in DMSO;30mg/ml in dimethyl formamide
form: crystalline solid
pka: 4.40±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 540211
Product name: PTP Inhibitor IV - CAS 329317-98-8 - Calbiochem
Packaging: 10mg
Price: $150
Updated: 2025/07/31

Cayman Chemical

Product number: 18458
Product name: PTP Inhibitor IV
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18458
Product name: PTP Inhibitor IV
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 18458
Product name: PTP Inhibitor IV
Purity: ≥98%
Packaging: 10mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 18458
Product name: PTP Inhibitor IV
Purity: ≥98%
Packaging: 25mg
Price: $305
Updated: 2024/03/01

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PTP Inhibitor IV Chemical Properties,Usage,Production

Uses

N,N''-[1,4-Phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1]-trifluoro-methanesulfonamide is an inhibitor of Protein tyrosine phosphatases (PTPs).

Biological Activity

ptp inhibitor iv is a protein tyrosine phosphatases (ptps) inhibitor.ptps are reported to be important in the regulation of various signal transduction processes. enzymes of this class are considered as potential therapeutic targets in the treatment of various diseases including inflammation, diabetes, as well as cancer. however, previously identified ptp inhibitors are peptide-based containing a highly charged component, which usually lack membrane permeability resulting in their limited utility in the inhibition of intracellular phosphatases.

in vitro

ptp inhibitor iv was identified as an uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido phosphate mimetic acting as a competitive, reversible, and active-site directed inhibitor. it was noticed that ptp inhibitor iv showed greatly increased potency not only on ptp1b but also on the phosphatases shp-2 and mu. moreover, the interaction of the second so2cf3 moiety in ptp inhibitor iv with conserved arg residue of ptp might explain the increased inhibitory potency towards other ptps in addition to ptp1b [1].

IC 50

1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 μm for shp-2, ptp1b, ptp-ε, ptp-meg-2, ptp-σ, ptp-β, and ptp-μ, respectively

storage

+4°C

References

[1] huang, p. ,ramphal, j.,wei, j., et al. structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases. bioor.med.chem. 11, 1835-1849 (2003).

PTP Inhibitor IV Preparation Products And Raw materials

Raw materials

Preparation Products

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PTP Inhibitor IV Suppliers

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329317-98-8, PTP Inhibitor IVRelated Search:

PTP Inhibitor IV

N,N'-[1,4-Phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1]-trifluoro-methanesulfonamide

-[1,4-Phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1]-trifluoro-methanesulfonamide

Methanesulfonamide, N,N'-[1,4-phenylenebis[(1-methylethylidene)-4,1-phenylene]]bis[1,1,1-trifluoro-

N,N'-((1,4-Phenylenebis(propane-2,2-diyl))bis(4,1-phenylene))bis(1,1,1-trifluoromethanesulfonamide)

PTP Inhibitor IV, 10 mM in DMSO

N,N'-((1,4-Phenylenebis(propane-2,2-diyl))bis(4,1-phenylene))bis(1,1,1-trifluoromethanesulfonamide)

329317-98-8

C26H26F6N2O4S2

Protein Tyrosine Phosphatase Inhibitor IV