ChemicalBook > CAS DataBase List > DeMethyleneberberine

DeMethyleneberberine

Product Name: DeMethyleneberberine
CAS No.: 25459-91-0
Chemical Name: DeMethyleneberberine
Synonyms: DeMethyleneberberine;DeMethyleneberberine USP/EP/BP;Demethyleneberberine - Bio-X ?;Demethyleneberberine, 10 mM in DMSO;2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoqu...;Dibenzo[a,g]quinoliziniuM,5,6-dihydro-2,3-dihydroxy-9,10-diMethoxy;2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium;9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol;2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium
CBNumber: CB62610281
Molecular Formula: C19H18NO4+
Formula Weight: 324.36
MOL File: 25459-91-0.mol

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DeMethyleneberberine Property

storage temp.: 4°C, protect from light
solubility: DMSO : 33.33 mg/mL (102.76 mM; Need ultrasonic)
form: powder
color: Yellow
InChI: InChI=1S/C19H17NO4/c1-23-18-4-3-11-7-15-13-9-17(22)16(21)8-12(13)5-6-20(15)10-14(11)19(18)24-2/h3-4,7-10,22H,5-6H2,1-2H3/p+1
InChIKey: HVTCKKMWZDDWOY-UHFFFAOYSA-O
SMILES: OC1=C(C=C2CC[N+]3=CC4=C(C(OC)=CC=C4C=C3C2=C1)OC)O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FD74150
Product name: Demethyleneberberine
Packaging: 5mg
Price: $86
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD74150
Product name: Demethyleneberberine
Packaging: 10mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0009603
Product name: Demethyleneberberine
Purity: 98.09%
Packaging: 10mg
Price: $290
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD74150
Product name: Demethyleneberberine
Packaging: 25mg
Price: $300
Updated: 2021/12/16

ApexBio Technology

Product number: N2087
Product name: Demethyleneberberine
Packaging: 10mg
Price: $450
Updated: 2021/12/16

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DeMethyleneberberine Chemical Properties,Usage,Production

Chemical Properties

Yellow crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Phellodendron chinense.

Uses

Demethyleneberberine is a naturally occurring alkaloid in plants that displays anti-adipogenic effects and is also shown to alleviate IBS.

Biological Activity

Demethyleneberberine, a berberine metabolite, is a mitochondria-targeted antioxidant isolated from Cortex Phellodendri chinensis th at exhibits multiple pharmacological activities including anti-microbial, anti-inflammatory, anti-diarrhea and anti-cancer. Demethyleneberberine alleviates ethanol-dependent oxidative stress by suppression of cytochrome CYP2E1 (P450 2E1), hypoxia inducible factor α (HIF-1α) and inducible nitric oxide synthase (iNOS). It appears th at demethyleneberberine attenuates non-alcoholic fatty liver disease (NAFLD) through activation of AMPK.

target

P450 (e.g. CYP17) | HIF | NOS

DeMethyleneberberine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DeMethyleneberberine manufacturers

R&D Scientific Inc.

Product: Demethyleneberberine 25459-91-0
Price: US $1400.00/g
Min. Order: 1g
Purity: 98
Supply Ability: 50 Kg
Release date: 2024-11-28

Shanghai Standard Technology Co., Ltd.

Product: Demethyleneberberine 25459-91-0
Price: US $0.00/mg
Min. Order: 10mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-06

Career Henan Chemical Co

Product: DeMethyleneberberine 25459-91-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

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DeMethyleneberberine

Dibenzo[a,g]quinoliziniuM,5,6-dihydro-2,3-dihydroxy-9,10-diMethoxy

9,10-dimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2,3-diol

2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoquinolinium

2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium

DeMethyleneberberine USP/EP/BP

2,3-dihydroxy-9,10-dimethoxy-5,6-dihydroisoquino[3,2-a]isoqu...

Demethyleneberberine, 10 mM in DMSO

Demethyleneberberine - Bio-X ?

25459-91-0

C19H18NO4

Alkaloids

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

pharmaceutical intermediate

phytochemical