(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol

Product Name: (S)-(+)-2-(N-MethylaMino)-3-phenylpropanol
CAS No.: 84773-29-5
Chemical Name: (S)-(+)-2-(N-MethylaMino)-3-phenylpropanol
Synonyms: N-Me-L-Phe-Ol;H-N-Me-Phe-ol;-2-(Methylamino);N-Me-Phenylalaninol;N-Me-D-Phenylalaninol;N-Methyl-L-phenylalaninol;N-methyl-D-phenylpropanol;N-Methyl-(S)-phenylalaninol;(S)-2-(Methylamino)-3-phenyl-1-propanol;(S)-2-(MethylaMino)-3-phenylpropan-1-ol
CBNumber: CB62614133
Molecular Formula: C10H15NO
Formula Weight: 165.23
MOL File: 84773-29-5.mol

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(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol Property

Melting point:: 68-70℃
Boiling point:: 294.9±20.0 °C(Predicted)
Density: 1.020±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.75±0.10(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure

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Safety

RIDADR: UN3259
HazardClass: 8
HS Code: 2922190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PH008400
Product name: (2S)-2-(methylamino)-3-phenyl-1-propanol
Purity: AldrichCPR
Packaging: 25MG
Price: $172
Updated: 2023/06/20

Apolloscientific

Product number: OR917507
Product name: (S)-2-(Methylamino)-3-phenylpropan-1-ol
Purity: 95%
Packaging: 250mg
Price: $305
Updated: 2021/12/16

AK Scientific

Product number: 3046AC
Product name: (S)-2-(Methylamino)-3-phenylpropan-1-ol
Packaging: 1g
Price: $492
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0033275
Product name: (S)-2-(METHYLAMINO)-3-PHENYLPROPAN-1-OL
Purity: 95.00%
Packaging: 5MG
Price: $499.98
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0033275
Product name: (S)-2-(METHYLAMINO)-3-PHENYLPROPAN-1-OL
Purity: 95.00%
Packaging: 1G
Price: $630
Updated: 2021/12/16

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(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol Chemical Properties,Usage,Production

Uses

N-Methyl-(S)-phenylalaninol is used in the synthesis of cyclopropane-fused oxazepanones which have antimycobacterial properties.

Synthesis

264128-49-6

84773-29-5

General procedure for the synthesis of (S)-(+)-2-(N-methylamino)-3-phenyl-1-propanol from 2-Boc-methylamino-3-phenyl-1-propanol: M: Deprotection of acid-unstable protecting groups (version 1) Dissolve 5 mmol of the feedstock in a wet trifluoroacetic acid-dichloromethane mixture (1:1, v/v) and stir the reaction for 4-7 hours. After completion of the reaction, the solvent was removed from the reaction mixture by evaporation. The residue was dissolved in dichloromethane and evaporated again to completely remove the residual trifluoroacetic acid. This dissolution-evaporation process was repeated three times to ensure complete removal of the acid. Finally, the residue was purified by column chromatography (using a dichloromethane-pentane gradient elution with an amino stationary phase) to give the target product. b) Synthesis of (S)-2-methylamino-3-phenyl-propan-1-ol (Ib) Compound Ia was subjected to deprotection reaction according to General Method M. Compound Ib was successfully obtained in 77% yield (630 mg, 3.8 mmol). Mass spectrometry (MS-ESI) analysis showed m/z 166 ([M + H]+, 100%). The results of the elemental analysis were consistent with the theoretical values: calculated values (%): C 72.69, H 9.15, N 8.48; measured values (%): C 72.66, H 9.13, N 8.47.

References

[1] Patent: WO2009/52970, 2009, A2. Location in patent: Page/Page column 68; 71

(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol Suppliers

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84773-29-5, (S)-(+)-2-(N-MethylaMino)-3-phenylpropanolRelated Search:

N-Methyl-(S)-phenylalaninol

N-Methyl-L-phenylalaninol

-2-(Methylamino)

(S)-(+)-2-(N-MethylaMino)-3-phenylpropanol

(S)-2-(MethylaMino)-3-phenylpropan-1-ol

N-Me-D-Phenylalaninol

N-Me-Phenylalaninol

(S)-2-(Methylamino)-3-phenyl-1-propanol

(S)-(+)-2-(N-Methylamino)-3-phenylpropan-1-ol

Benzenepropanol, β-(methylamino)-, (βS)-

N-Me-L-Phe-Ol

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N-methyl-D-phenylpropanol

84773-29-5