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N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide

Product Name
N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide
CAS No.
301675-24-1
Chemical Name
N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide
Synonyms
IRAK-4 protein kinase inhibitor 2;Benzamide, N-1H-benzimidazol-2-yl-3-nitro-;3-nitro-N-(1H-benzoimidazol-2-yl)-benzamide;N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide;N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide-2;IRAK-4 protein kinase inhibitor 2, 10 mM in DMSO;Inhibitor,inhibit,IRAK-4,interleukin-1,IRAK-4 protein kinase inhibitor 2,immune,IRAK 4 protein kinase inhibitor 2,IRAK,Interleukin-1 receptor associated kinase,inflammatory,IL-1,IL-1R associated kinase,IRAK4 protein kinase inhibitor 2
CBNumber
CB62624242
Molecular Formula
C14H10N4O3
Formula Weight
282.2542
MOL File
301675-24-1.mol
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N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide Property

storage temp. 
Store at -20°C
solubility 
DMSO : 10 mg/mL (35.43 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-M1436
Product name
IRAK-4proteinkinaseinhibitor2
Packaging
1g
Price
$275
Updated
2021/12/16
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N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide Chemical Properties,Usage,Production

Uses

IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders[1].

Biological Activity

IRAK-4 protein kinase inhibitor 2 (compound 1) is a potent inhibitor of interleukin-1 (IL-1) receptor-associated kinase-4 (IRAK-4), with an IC50 of 4 μM. IRAK-4 protein kinase inhibitor 2 can be used for the research of inflammatory and immune-related conditions or disorders[1]. IRAK-4 protein kinase inhibitor 2 (compound 1) also inhibits IRAK-1, with an IC50 of <10 μM[1].

IC 50

IRAK4: 4 μM (IC50)

References

[1]. Powers JP, et, al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.

N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide Suppliers

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301675-24-1, N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMideRelated Search:


  • N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide
  • N-(1H-benzo[d]iMidazol-2-yl)-3-nitrobenzaMide-2
  • 3-nitro-N-(1H-benzoimidazol-2-yl)-benzamide
  • Benzamide, N-1H-benzimidazol-2-yl-3-nitro-
  • IRAK-4 protein kinase inhibitor 2
  • Inhibitor,inhibit,IRAK-4,interleukin-1,IRAK-4 protein kinase inhibitor 2,immune,IRAK 4 protein kinase inhibitor 2,IRAK,Interleukin-1 receptor associated kinase,inflammatory,IL-1,IL-1R associated kinase,IRAK4 protein kinase inhibitor 2
  • IRAK-4 protein kinase inhibitor 2, 10 mM in DMSO
  • 301675-24-1