1-Bromo-3,5-dimethyladamantane
Uses- Product Name
- 1-Bromo-3,5-dimethyladamantane
- CAS No.
- 941-37-7
- Chemical Name
- 1-Bromo-3,5-dimethyladamantane
- Synonyms
- 1-Bromo-3,5-Dimethyl;Memantine impurity D;MeMantine Related CoMpound D;(1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane;NSC 102293;Memantine USP RC D;MeMantine IMpurity B;Adamantane Impurity D;1-Bromo-3,5-dimethyladama;Hydrochloride intermediate
- CBNumber
- CB6263645
- Molecular Formula
- C12H19Br
- Formula Weight
- 243.18
- MOL File
- 941-37-7.mol
1-Bromo-3,5-dimethyladamantane Property
- Boiling point:
- 201 °C (lit.)
- Density
- 1.224 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.52(lit.)
- Flash point:
- 228 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Dichloromethane (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Colourless to Pale Yellow
- Specific Gravity
- 1.224
- BRN
- 1927514
- InChI
- InChI=1S/C12H19Br/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8H2,1-2H3
- InChIKey
- QUCXLVDIVQWYJR-UHFFFAOYSA-N
- SMILES
- C12(Br)CC3(C)CC(CC(C)(C3)C1)C2
- CAS DataBase Reference
- 941-37-7(CAS DataBase Reference)
Safety
- Hazard Codes
- C
- Risk Statements
- 34-36
- Safety Statements
- 26-27-36/37/39-45
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2903890002
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S694541
- Product name
- 1-BROMO-3,5-DIMETHYLADAMANTANE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- PHR2583
- Product name
- Memantine Related Compound D
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100?mg
- Packaging
- 100MG
- Price
- $392
- Updated
- 2025/07/31
- Product number
- 187844
- Product name
- 1-Bromo-3,5-dimethyladamantane
- Purity
- 98%
- Packaging
- 5g
- Price
- $68.7
- Updated
- 2025/07/31
- Product number
- 1380546
- Product name
- Memantine Related Compound D
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 50mg
- Price
- $1300
- Updated
- 2025/07/31
- Product number
- B1821
- Product name
- 1-Bromo-3,5-dimethyladamantane
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $51
- Updated
- 2025/07/31
1-Bromo-3,5-dimethyladamantane Chemical Properties,Usage,Production
Uses
1-Bromo-3,5-dimethyladamantane (cas# 941-37-7) is a compound useful in organic synthesis.
Description
1-Bromo-3,5-dimethyladamantane is a precursor substance of memantine and memantine hydrochloride (MH), which can be synthesised by direct amination with thiourea. MH is an FDA-approved first-line treatment for moderate to severe Alzheimer's disease.
Chemical Properties
Clear Colorless Oil
Uses
1-Bromo-3,5-dimethyladamantane was used in the one pot synthesis of 1,3-dicarbonyl adamantanes. It was also used in the synthesis of 3,5-dimethyladamantan-1-ol.
Synthesis
702-79-4
941-37-7
A) Add 59.9 g (0.345 mol) of bromine, 10 g (0.075 mol) of anhydrous aluminum trichloride, and 37.8 g of 1,2-dichloroethane to the reactor with thorough stirring; B) Heat the reaction mixture A to 15°C; C) Add 50 g (0.3 mol) of 1,3-dimethyladamantane to the mixture obtained in step B, and absorb the resulting gas using a 5% sodium hydroxide solution; D) Add 400 g of saturated sodium bisulfite solution to reaction mixture B until the red color of the reaction solution completely disappears, and separate the organic phase C and the aqueous phase D; and D) Add 400 g of saturated sodium bisulfite solution to the reaction mixture B until the red color of the reaction solution completely disappears, and separate the organic phase C and the aqueous phase D; E) Wash the organic phase C with 400 g of water, and then dry it with 20 g of anhydrous sodium sulfate; F) Perform distillation on the organic phase C obtained in step E to obtain the crude product E; G) Perform decompression distillation on the crude product E to obtain the 1-(3-methyladamantyl)-1,3-dimethyladamantane. G) the crude product E was distilled under reduced pressure to obtain 1-bromo-3,5-dimethyladamantane in 92% yield and ≥99% purity by gas chromatography.
References
[1] Patent: CN104592034, 2016, B. Location in patent: Paragraph 0092-0099
[2] Asian Journal of Chemistry, 2012, vol. 24, # 11, p. 5107 - 5110
[3] Russian Journal of Organic Chemistry, 2015, vol. 51, # 2, p. 184 - 187
[4] Zh. Org. Khim., 2015, vol. 51, # 2, p. 196 - 199
[5] Patent: US5061703, 1991, A
1-Bromo-3,5-dimethyladamantane Preparation Products And Raw materials
Raw materials
Preparation Products
1-Bromo-3,5-dimethyladamantane Suppliers
- Tel
- --
- Fax
- --
- brunschwig@brunschwig.nl
- Country
- The Netherlands
- ProdList
- 4996
- Advantage
- 67
View Lastest Price from 1-Bromo-3,5-dimethyladamantane manufacturers
- Product
- 1-Bromo-3,5-dimethyladamantane 941-37-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-09-26
- Product
- 1-Bromo-3,5-dimethyladamantane 941-37-7
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-30
- Product
- 1-Bromo-3,5-dimethyladamantane 941-37-7
- Price
- US $10.00-8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-04