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EVP-6124 (hydrochloride)

Product Name
EVP-6124 (hydrochloride)
CAS No.
550999-74-1
Chemical Name
EVP-6124 (hydrochloride)
Synonyms
MT4666);EVP-6124 Hcl;EVP6124;EVP 6124;Encenicline, HCl salt;EVP-6124 (hydrochloride);Encenicline hydrochloride;Encenicline HCl salt (EVP6124;Encenicline hydrochloride (EVP-6124);Encenicline (EVP-6124) hydrochloride;Encenicline hydrochloride, 10 mM in DMSO
CBNumber
CB62645139
Molecular Formula
C16H18Cl2N2OS
Formula Weight
357.29792
MOL File
550999-74-1.mol
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EVP-6124 (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥100.4 mg/mL in EtOH with gentle warming; ≥17.87 mg/mL in DMSO
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
E1453
Product name
EVP-6124 Hydrochloride
Packaging
10MG
Price
$168
Updated
2025/07/31
Cayman Chemical
Product number
30073
Product name
EVP-6124 (hydrochloride)
Packaging
5mg
Price
$111
Updated
2024/03/01
Cayman Chemical
Product number
30073
Product name
EVP-6124 (hydrochloride)
Packaging
50mg
Price
$929
Updated
2024/03/01
Cayman Chemical
Product number
30073
Product name
EVP-6124 (hydrochloride)
Packaging
10mg
Price
$210
Updated
2024/03/01
Cayman Chemical
Product number
30073
Product name
EVP-6124 (hydrochloride)
Packaging
25mg
Price
$493
Updated
2024/03/01
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EVP-6124 (hydrochloride) Chemical Properties,Usage,Production

Uses

Encenicline hydrochloride is a selective partial agonist of the a7 nicotinic acetylcholine receptor being developed for the cognitive impairment in Alzheimer’s disease and schizophrenia.

in vivo

Encenicline hydrochloride has good brain penetration and an adequate exposure time. Encenicline hydrochloride (0.3 mg/kg, p.o.) significantly restores memory function in scopolamine-treated rats (0.1 mg/kg, i.p.) in an object recognition task (ORT). Although donepezil at 0.1 mg/kg, p.o. or Encenicline hydrochloride at 0.03 mg/kg, p.o. did not improve memory in this task, co-administration of these sub-efficacious doses fully restored memory. In a natural forgetting test, an ORT with a 24 h retention time, Encenicline hydrochloride improved memory at 0.3 mg/kg, p.o. This improvement is blocked by the selective α7 nAChR antagonist methyllycaconitine (0.3 mg/kg, i.p. or 10 μg, i.c.v.). Encenicline hydrochloride is found to bind moderately to rat plasma proteins with a mean fu of 0.11±0.01 (mean±SD) or 11%. Over a range of 0.1-30 mg/kg, p.o., Encenicline hydrochloride demonstrates proportional dose escalation. Tmax is at 4 h in plasma and 2 h brain, although the brain concentrations remained similar between 2 and 8 h. The B:P ratios are 1.7-5.1 between 1 and 8 h[1]. Pharmacokinetic studies have shown that Encenicline hydrochloride (0.4 mg/kg, i.p.) reaches peak brain concentration 2 hr after administration and remains at effective concentrations for at least 4 hr. Encenicline hydrochloride is administered to WT mice at ZT0 (0.4 mg/kg i.p single dose) and significantly increases the saturation index of NMDARs in slices obtained 4 hr later without causing prolonged wakefulness or enhanced locomotor activity [2].

EVP-6124 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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EVP-6124 (hydrochloride) Suppliers

CHINA 61 United States 8 Global 69
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
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United States
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2782
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58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
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60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
ApexBio Technology
Tel
--
Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81

550999-74-1, EVP-6124 (hydrochloride)Related Search:


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  • EVP-6124 hydrochloride (Encenicline hydrochloride)
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  • Encenicline hydrochloride
  • Encenicline hydrochloride (EVP-6124)
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  • MT4666)
  • Nicotinic acetylcholine receptors,EVP 6124,Encenicline hydrochloride,EVP-6124,Encenicline,inhibit,nAChR,Inhibitor,EVP6124
  • Encenicline (EVP-6124) hydrochloride
  • Encenicline hydrochloride, 10 mM in DMSO
  • 550999-74-1
  • C16H17ClN2OSHCl
  • Inhibitors