Kalydeco benzenesulfonate
- Product Name
- Kalydeco benzenesulfonate
- CAS No.
- 1134822-09-5
- Chemical Name
- Kalydeco benzenesulfonate
- Synonyms
- VX770 benzenesulfonate;VX-770 benzenesulfonate;VX 770 benzenesulfonate;Kalydeco benzenesulfonate;Ivacaftor (benzenesulfonate);Ivacaftor benzenesulfonate (VX770);Ivacaftor benzenesulfonate (VX-770 benzenesulfonate;N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide.besylate
- CBNumber
- CB62666642
- Molecular Formula
- C30H34N2O6S
- Formula Weight
- 550.67
- MOL File
- 1134822-09-5.mol
Kalydeco benzenesulfonate Property
- storage temp.
- Store at -20°C
- solubility
- ≥55.1 mg/mL in DMSO; insoluble in H2O; ≥13.86 mg/mL in EtOH with gentle warming
- form
- solid
N-Bromosuccinimide Price
- Product number
- A100828
- Product name
- IvacaftorBenzenesulfonate
- Packaging
- 1mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A100828
- Product name
- IvacaftorBenzenesulfonate
- Packaging
- 2mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- A100828
- Product name
- IvacaftorBenzenesulfonate
- Packaging
- 10mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- A3510
- Product name
- Ivacaftorbenzenesulfonate
- Packaging
- 25mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- A3510
- Product name
- Ivacaftorbenzenesulfonate
- Packaging
- 100mg
- Price
- $650
- Updated
- 2021/12/16
Kalydeco benzenesulfonate Chemical Properties,Usage,Production
Uses
Ivacaftor Benzenesulfonate is a salt of Ivacaftor, a novel agent for the treatment of cystic fibrosis.
Biological Activity
ivacaftor (vx-770) is a cftr potentiator approved for patients with the g551d mutation of cystic fibrosis, which accounts for 4-5% cases of cystic fibrosis.
in vitro
in recombinant cells vx-770 increased cftr channel open probability (p(o)) in both the f508del processing mutation and the g551d gating mutation. vx-770 also increased cl(-) secretion in cultured human cf bronchial epithelia (hbe) carrying the g551d gating mutation on one allele and the f508del processing mutation on the other allele by approximately 10-fold, to approximately 50% of that observed in hbe isolated from individuals without cf [1].
in vivo
at day 28, in the group of subjects who received 150 mg of vx-770, the median change in the nasal potential difference (in response to the administration of a chloride-free isoproterenol solution) from baseline was -3.5 mv (range, -8.3 to 0.5; p=0.02 for the within-subject comparison, p=0.13 vs. placebo), and the median change in the level of sweat chloride was -59.5 mmol per liter (range, -66.0 to -19.0; p=0.008 within-subject, p=0.02 vs. placebo) [2].
IC 50
25 nm (f508del-cftr);100 nm (g551d-cftr) [1]
Kalydeco benzenesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
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