1-PalMitoyl-2-arachidoyllecithin

Product Name: 1-PalMitoyl-2-arachidoyllecithin
CAS No.: 35418-58-7
Chemical Name: 1-PalMitoyl-2-arachidoyllecithin
Synonyms: 16:0-20:4 PC - IsoPure;IIZPXYDJLKNOIY-JXPKJXOSSA-N;1-PalMitoyl-2-arachidoyllecithin;1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PC;(2-{[(2R)-3-(Hexadecanoyloxy)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propyl phosphonato]oxy}ethyl)trimethylazanium
CBNumber: CB62694283
Molecular Formula: C44H80NO8P
Formula Weight: 782.081661
MOL File: 35418-58-7.mol

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1-PalMitoyl-2-arachidoyllecithin Property

storage temp.: -20°C
solubility: Chloroform: Soluble
form: liquid
color: Colorless to light yellow

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Safety

Hazard Codes: Xn
Risk Statements: 63-20-22-36/38-40-48/20/22-67
Safety Statements: 26-36/37
RIDADR: UN 1888 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25658
Product name: 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PC
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 25658
Product name: 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PC
Purity: ≥95%
Packaging: 25mg
Price: $267
Updated: 2024/03/01

Cayman Chemical

Product number: 25658
Product name: 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PC
Purity: ≥95%
Packaging: 100mg
Price: $456
Updated: 2024/03/01

Cayman Chemical

Product number: 25658
Product name: 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PC
Purity: ≥95%
Packaging: 1mg
Price: $35
Updated: 2021/12/16

Usbiological

Product number: 158536
Product name: 1-Palmitoyl-2-arachidoyllecithin
Packaging: 1mg
Price: $446
Updated: 2021/12/16

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1-PalMitoyl-2-arachidoyllecithin Chemical Properties,Usage,Production

Description

1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.

Uses

16:0-20:4 PC is suitable for use:

in the preparation of auto-oxidised phospholipid for electrospray ionisation mass spectroscopic (ESI-MS) analysis
in liposome preparation for the treatment of organoid
as antigen in enzyme linked immunosorbent assay (ELISA) for the detection of autoantibodies to phospholipids

Uses

1-Palmitoyl-2-arachidoyllecithin, is a phospholipid, that can be used for the studies, and elevation of autoantibodies against oxidized palmitoyl arachidonoyl phosphocholine in patients with hypertension and myocardial infarction.

General Description

Phosphatidylcholine (PC) is one of the major glycerophospholipids of the eukaryotic membranes. PC is zwitterionic. PC is synthesized via two pathways in higher eukaryotes like the triple methylation of phosphatidylethanolamine and the cytidine diphosphate (CDP)-choline pathway.

Biochem/physiol Actions

Phosphatidylcholine (PC) is essential for maintaining the structure and functions of the membrane. PC is the substrate for sphingomyelin synthesis. PC is the precursor for various second messenger like phosphatidic acid, lysophosphatidic acid, diacylglycerol. PC is the dominant phospholipid present in cancer and neo-neoplastic tissues. Level of 16:0-20:4 PC is less in multiple myeloma cells than in normal plasma cells.

References

[1] PETER BRETSCHER. Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.[J]. EMBO Molecular Medicine, 2015, 7 5: 593-607. DOI: 10.15252/emmm.201404702
[2] YURY I. MILLER J S. Context-Dependent Role of Oxidized Lipids and Lipoproteins in Inflammation[J]. Trends in Endocrinology & Metabolism, 2017, 31 1: 143-152. DOI: 10.1016/j.tem.2016.11.002
[3] B GABRIEL GUGIU. Protein targets of oxidized phospholipids in endothelial cells.[J]. Journal of Lipid Research, 2008, 49 3: 510-520. DOI: 10.1194/jlr.m700264-jlr200
[4] MD AMIR HOSSEN. Decreased level of phosphatidylcholine (16:0/20:4) in multiple myeloma cells compared to plasma cells: a single-cell MALDI–IMS approach[J]. Analytical and Bioanalytical Chemistry, 2015, 407 18: 5273-5280. DOI: 10.1007/s00216-015-8741-z

1-PalMitoyl-2-arachidoyllecithin Preparation Products And Raw materials

Raw materials

Preparation Products

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1-PalMitoyl-2-arachidoyllecithin Suppliers

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35418-58-7, 1-PalMitoyl-2-arachidoyllecithinRelated Search:

1-PalMitoyl-2-arachidoyllecithin

IIZPXYDJLKNOIY-JXPKJXOSSA-N

1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PC

(2-{[(2R)-3-(Hexadecanoyloxy)-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propyl phosphonato]oxy}ethyl)trimethylazanium

16:0-20:4 PC - IsoPure

35418-58-7

Aliphatics, Glycerols, Fatty Acid Derivatives & Lipids, Inhibitors