ChemicalBook > CAS DataBase List > Neohesperidin

Neohesperidin

Product Name: Neohesperidin
CAS No.: 13241-33-3
Chemical Name: Neohesperidin
Synonyms: NSC 31048;Neohesperdin;NEOHESPERIDIN;Businessperson;Neohesperidin-RM;NEOHESPERIDIN (PR);(2S)-Neohesperidin;Citrus Polyphenols;Neohesperidin, 90%+;Hesperidin Impurity 9
CBNumber: CB6291569
Molecular Formula: C28H34O15
Formula Weight: 610.56
MOL File: 13241-33-3.mol

Less

Neohesperidin Property

Melting point:: 239-243°C
Boiling point:: 933.7±65.0 °C(Predicted)
Density: 1.65±0.1 g/cm3(Predicted)
vapor pressure: 0Pa at 20℃
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Pyridine (Slightly)
pka: 7.14±0.40(Predicted)
form: Solid
color: White to Off-White
biological source: plant (orange)
Water Solubility: 3.98mg/L at 20℃
BRN: 74945
InChIKey: ARGKVCXINMKCAZ-RTFRIYMLSA-N
LogP: -0.69 at 20℃
CAS DataBase Reference: 13241-33-3(CAS DataBase Reference)

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: DJ2981400
F: 10-21
HS Code: 29389090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3213
Product name: Neohesperidin
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $497
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL89741
Product name: Neohesperidin
Purity: phyproof<SUP>®</SUP> Reference Substance
Packaging: 10 mg
Price: $277
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1458042
Product name: Neohesperidin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 30mg
Price: $909
Updated: 2025/07/31

Sigma-Aldrich

Product number: 40927
Product name: Neohesperidin
Purity: analytical standard
Packaging: 10mg
Price: $322
Updated: 2021/12/16

TCI Chemical

Product number: N1121
Product name: Neohesperidin
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $97
Updated: 2025/07/31

Less

Neohesperidin Chemical Properties,Usage,Production

Description

Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities. In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-κB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-κB ligand (RANKL). In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity. In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.

Chemical Properties

White powder, easily soluble in methanol and almost insoluble in ether, derived from trifoliate orange peel, sour orange immature fruit, and various citrus fruits.

Uses

Neohesperidin can be used in cosmetic products and as a sweetening agent in food & beverages, an antioxidant flavanone glycoside

Uses

Neohesperidin exhibits lipid-regulating effects in vivo and in vitro. It is a main flavonoid in citrus byproducts (CBP) which possesses anti-oxidant activity.

Definition

ChEBI: Neohesperidin is a flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. It has a role as an antineoplastic agent and a plant metabolite. It is a neohesperidoside, a disaccharide derivative, a dihydroxyflavanone, a member of 3'-hydroxyflavanones, a monomethoxyflavanone, a flavanone glycoside and a member of 4'-methoxyflavanones. It is functionally related to a hesperetin.

References

[1] ZHEN TAN . Neohesperidin suppresses osteoclast differentiation, bone resorption and ovariectomised-induced osteoporosis in mice[J]. Molecular and Cellular Endocrinology, 2017, 439: Pages 369-378. DOI: 10.1016/j.mce.2016.09.026
[2] HAOSHU WU. Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis.[J]. Pharmacology, 2017, 100 3-4: 115-126. DOI: 10.1159/000452492
[3] JIA S, HU Y, ZHANG W, et al. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-Ay mice[J]. Food & Function, 2015, 3: 878-886. DOI: 10.1039/c4fo00993b

Neohesperidin Preparation Products And Raw materials

Raw materials

Preparation Products

Neosperidin dihydrochalcone

Less

Neohesperidin Suppliers

Americas 1 Canada 1 CHINA 434 China Hong Kong 1 Europe 1 France 2 Germany 4 India 6 Japan 2 Switzerland 1 United Kingdom 9 United States 36 USA 1 Global 499

Sichuan Benepure Pharmaceutical Co., Ltd.

Tel: 028-028-86798880 13308041363
Fax: 028-86799924
Email: online@benepure.com
Country: China
ProdList: 129
Advantage: 58

Zhuhai Anzhe Biotechnology Co,Ltd.

Tel: 13169972583
Email: 513211116@qq.com
Country: China
ProdList: 3005
Advantage: 58

Hubei Hongfuda Biotechnology Co., Ltd.

Tel: 19107255884
Email: 2013537414@qq.com
Country: China
ProdList: 500
Advantage: 58

Nantong Feiyu Biological Technology CO.,LTD

Tel: 0513-68819626; 15152877458
Fax: 0513-68669626
Email: feiyubio@163.com
Country: China
ProdList: 4817
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2766
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3249
Advantage: 55

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

Zouping Mingxing Chemical Co.,Ltd.

Tel: 86-13605431940 13605431940
Fax: 0086-0543-2240079
Email: zpmxchemical@126.com
Country: China
ProdList: 1490
Advantage: 62

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Cheng Du Pufeide Biotechnology Co., Ltd.

Tel: 028-82610909 13388174823
Fax: 8171-1798
Email: scglp@glp-china.com
Country: China
ProdList: 1064
Advantage: 58

Chengdu Herbpurify Co.Ltd.

Tel: 2355253622; 18981954830
Fax: 086-28-85377358
Email: 2355253622@qq.com;
Country: China
ProdList: 1103
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Vientiane Tianjin Hengyuan Technology Co., Ltd.

Tel: 15722085254
Fax: 022-26358246
Email: phytochemical@126.com
Country: China
ProdList: 813
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 42446
Advantage: 60

ShangHai D&B Biological Science and Technology Co.Ltd

Tel: 400-008-9730,021-54359730 400-008-9730
Fax: 021-54353864
Email: info@chemxyz.com
Country: China
ProdList: 3091
Advantage: 60

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7778
Advantage: 56

Chengdu HuaXia Chemical Reagent Co. Ltd

Tel: 400-1166-196 13458535857
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 13350
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2880
Advantage: 58

Shaanxi Huike Botanical Development Co., Ltd

Tel: +86-29-62663046
Fax: +86-29-82606529
Email: market@huikes.com
Country: China
ProdList: 61
Advantage: 62

Shaanxi Pioneer Biotech Co., Ltd.

Tel: 13720616393；029-84385017-8003 13720616393
Fax: 029-84385017
Email: sales@pioneerbiotech.com
Country: China
ProdList: 777
Advantage: 56

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Less

View Lastest Price from Neohesperidin manufacturers

Changsha Staherb Natural Ingredients Co., Ltd.

Product: Neohesperidin 13241-33-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 95%, 98%
Supply Ability: 1000kg
Release date: 2022-10-08

Watson Biotechnology Co.,Ltd

Product: Neohesperidin 13241-33-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20MT
Release date: 2024-09-19

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Neohesperidin 13241-33-3
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-12-11

13241-33-3, NeohesperidinRelated Search:

Hesperetin Diethylstilbestrol HESPERIDINASE Hesperidin Methyl hesperidin Neosperidin dihydrochalcone 1-(4-PROPOXY-PHENYL)-ETHANONE 4-N-BUTOXYBENZALDEHYDE 4-CHROMANONE BETA-PHENYLPROPIOPHENONE 7-METHOXYFLAVANONE PHENYL-BETA-D-GLUCOPYRANOSIDE 3-Butoxyphenol L-LYXOSE PINOCEMBRIN 3'-HYDROXYFLAVANONE 7-HYDROXYFLAVANONE Diethylene glycol monobutyl ether

HESPERETIN-7-NEOHESPERIDOSIDE

HESPERETIN-7-O-NEOHESPERIDOSIDE

Neohesperidin HPLC 96% Min

(s)-a-d-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)

4h-1-benzopyran-4-one,2,3-dihydro-7-((2-o-(6-deoxy-alpha-l-mannopyranosyl)-bet

Neohesperidin≥ 98% (HPLC)

7-[[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxy-6-methyl-2-oxanyl)oxy]-2-oxanyl]oxy]-5-hydroxy-2-(3-hydroxy-5-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one

Neohesperidin 95% HPLC

(S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

(S)-4'-METHOXY-3',5,7-TRIHYDROXYFLAVONE-7-[2-O-(ALPHA-L-RHAMNOPYRANOSYL)-BETA-D-GLUCOPYRANOSIDE]

NEOHESPERIDIN

NEOHESPERIDIN (PR)

(S)-7-[[2-O-6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Neohesperdin

(s)-4'-methoxy-3',5,7-trihydroxyflavanone-7-[2-o-(α-l-rhamnopyranosyl)-β-d-glucopyranoside]

NEOHESPERIDIN WITH HPLC

rhamnopyranosyl-(1→2)-β-D-glucopyranoside

Neohesperidin，Hesperetin 7-neohesperidoside

(2S)-2-(3-Hydroxy-4-methoxyphenyl)-5-hydroxy-7-(2-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)-2,3-dihydro-4H-1-benzopyran-4-one

(2S)-7-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Neohesperidin, 98%, from Poncirus trifoliata (L.) Raf.

4H-1-Benzopyran-4-one,7-[[2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-,(2S)-

(2S)-Neohesperidin

NSC 31048

HESPERETIN-7-NEOHESPERIDOSIDE hplc

Neohesperidin, froM Poncirus trifoliata(L.)Raf.

Neohesperidin Standard

4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-

(S)-7-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one

Hesperidin Impurity 9

(2S)-7-[2-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyloxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Neohesperidin USP/EP/BP

Businessperson

(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one

Neohesperidin (Hesperetin 7-O-neohesperidoside)

Neohesperidin, 90%+

Neohesperidin ((S)-5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(a (1458042)

(2S)-7-{[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one

Neohesperidin (6CI, 8CI)

(2RS)-7-[[2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one (neohesperidin)

Citrus Polyphenols

Neohesperidin-RM

(S)-7-[[2-O-6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Neohesperidin, 10 mM in DMSO

13241-33-3

C28H34O15

Natural Dyes

Disaccharide

Carbohydrates

Biochemicals and Reagents

BioChemical

CITRIMORE

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Flavanones