ChemicalBook > CAS DataBase List > 4-Hydroxypyridine

4-Hydroxypyridine

Product Name: 4-Hydroxypyridine
CAS No.: 626-64-2
Chemical Name: 4-Hydroxypyridine
Synonyms: PYRIDIN-4-OL;4-PYRIDINOL;4HYDROXYPRIDINE;4-Hydroxypyride;1H-Pyridin-4-ol;Compound Fr14055;4-HYDROXYPYRIDINE; 4-Hydroxypyridone ;TIMTEC-BB SBB000030;4-hydroxyl pyridine
CBNumber: CB6303828
Molecular Formula: C5H5NO
Formula Weight: 95.1
MOL File: 626-64-2.mol

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4-Hydroxypyridine Property

Melting point:: 150-151 °C (lit.)
Boiling point:: 230-235 °C/12 mmHg (lit.)
Density: 1.1418 (rough estimate)
refractive index: 1.5939 (estimate)
Flash point:: 221 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 3.2(at 20℃)
form: Powder or Chunks
color: Beige to light brown
Water Solubility: Soluble
BRN: 105800
InChIKey: GCNTZFIIOFTKIY-UHFFFAOYSA-N
LogP: -1.300 (est)
CAS DataBase Reference: 626-64-2(CAS DataBase Reference)
NIST Chemistry Reference: 4-Pyridinol(626-64-2)
EPA Substance Registry System: 4-Pyridinol (626-64-2)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36-37/39-39
WGK Germany: 3
RTECS: UU7701450
F: 3-8-10
Hazard Note: Harmful/Irritant
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 120618
Product name: 4-Hydroxypyridine
Purity: 95%
Packaging: 25g
Price: $68.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: CDS013613
Product name: 4-hydroxypyridine
Purity: AldrichCPR
Packaging: 1G
Price: $73.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 120618
Product name: 4-Hydroxypyridine
Purity: 95%
Packaging: 100g
Price: $133
Updated: 2025/07/31

TCI Chemical

Product number: H0332
Product name: 4-Hydroxypyridine
Purity: >99.0%(GC)
Packaging: 25g
Price: $80
Updated: 2025/07/31

Sigma-Aldrich

Product number: 120618
Product name: 4-Hydroxypyridine
Purity: 95%
Packaging: 500g
Price: $375.5
Updated: 2025/07/31

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4-Hydroxypyridine Chemical Properties,Usage,Production

Description

4-Hydroxypyridine, available from pyridylpyridinium chloride hydrochloride, is the substrate for diodone and its n-propyl ester, propyliodone. 4-Hydroxypyridine (4-HP) is a non-nucleophilic analog of the product phenol found to bind specifically to and stabilize the aminoacrylate intermediate. When 4-HP is added to Tyrosine phenol-lyase (TPL) reactions, an absorption peak at 340 nm is observed. The formation of the 340 nm peak correlates with the decay of the quinonoid intermediate peak at 505 nm, with a clean isosbestic point, and the observed rate constants show an inverse dependence on the concentration of 4-HP. These results confirm that the observed peak at 340 nm is due to the formation of the amino acrylate intermediate[1-2].

Chemical Properties

Beige crystalline powder

Uses

4-Hydroxypyridine was used in the synthesis of (Ag₃MoO₃F₃) (Ag₃MoO₄)Cl by hydro(solvato)thermal methods. It was used as model compound to study the natural photodegradation of representative aquatic environmental contaminants.

Definition

ChEBI: A monohydroxypyridine that is pyridine in which the hydrogen at position 4 has been replaced by a hydroxy group.

Synthesis

1692-15-5

626-64-2

Under standard reaction conditions, 10 equivalents of CuSO4-5H2O (0.049 g, 0.2 mmol) were mixed with 6.7 mol% EA (20 mg) in methanol, followed by the addition of 2 mmol of pyridine-4-boronic acid. The reaction mixture was placed in a preheated oil bath, maintained at 60 °C with continuous stirring and the reaction was carried out at atmospheric pressure. The progress of the reaction was monitored by TLC and after completion of the reaction, the mixture was washed twice with hot ethyl acetate to remove unreacted reactants and by-products. After removal of hot ethyl acetate by evaporation, the crude product was purified by column chromatography on silica gel (260 mesh) with an eluent ratio of petroleum ether:ethyl acetate (25:75). The recovered catalyst could be used directly in the next round of reaction. The structure of the final product 4-hydroxypyridine was confirmed by 1H NMR and 13C NMR spectra.

Purification Methods

Crystallise 4-pyridone from H2O or wet CHCl3 as the monohydrate. It loses H2O on drying in vacuo over H2SO4. Store it over KOH because it is hygroscopic.[Beilstein 21 III/IV 446, 21/7 V 152.]

References

[1] Yates, F. S. “2.09 – Pyridines and their Benzo Derivatives: (vi) Applications.”Comprehensive Heterocyclic Chemistry 2 (1984): 511-524.
[1] Robert S Phillips, Olivia Bauer. “Characterization of aminoacrylate intermediates of pyridoxal-5’-phosphate dependent enzymes.” Methods in enzymology 685 (2023): 199–224.

4-Hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-DICHLORO-5-NITROPYRIDINE 3-AMINO-4-METHOXYPYRIDINE 3,4-Diaminopyridine 4-Dimethylaminopyridine

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View Lastest Price from 4-Hydroxypyridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Hydroxypyridine 626-64-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kgs
Release date: 2021-11-10

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Hydroxypyridine 626-64-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-11

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Hydroxypyridine 626-64-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-05

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Compound Fr14055

626-64-2

C5H4NO

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626-64-2