SMER18

Product Name: SMER18
CAS No.: 944153-47-3
Chemical Name: SMER18
Synonyms: SMER18;CS-2054;SMER18,SMER-18;Reaxys ID: 18302282;(Z)-1-(4-Chlorophenyl)-3-((3-hydroxyphenyl)amino)but-2-en-1-one;2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-
CBNumber: CB63041460
Molecular Formula: C16H14ClNO2
Formula Weight: 287.74
MOL File: 944153-47-3.mol

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SMER18 Property

Boiling point:: 458.7±45.0 °C(Predicted)
Density: 1.298±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 9.83±0.10(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb611783
Product name: SMER-18
Packaging: 10mg
Price: $615.4
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611783
Product name: SMER-18
Packaging: 50mg
Price: $1802
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611783
Product name: SMER-18
Packaging: 100mg
Price: $2512.6
Updated: 2021/12/16

Crysdot

Product number: CD31000130
Product name: SMER18
Purity: 98+%
Packaging: 5mg
Price: $243
Updated: 2021/12/16

Crysdot

Product number: CD31000130
Product name: SMER18
Purity: 98+%
Packaging: 10mg
Price: $347
Updated: 2021/12/16

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SMER18 Chemical Properties,Usage,Production

Uses

SMER18 is a small molecule enhancer of rapamycin which act as a mTOR-independent autophagy inducer. Target: mTOR SMER18 induces autophagy independently of Rapamycin in mammalian cells, enhancing the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein, which are associated with Huntington's disease and familial Parkinson's disease, respectively. SMER18 acts either independently or downstream of the target of Rapamycin, attenuates mutant huntingtin-fragment toxicity in Huntington's disease cell and Drosophila melanogaster models, which suggests therapeutic potential.

References

[1] Sarkar S, et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol. 2007 Jun;3(6):331-338. DOI:10.1038/nchembio883

SMER18 Preparation Products And Raw materials

Raw materials

Preparation Products

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SMER18 Suppliers

China 24 United States 6 Global 30

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944153-47-3, SMER18Related Search:

SMER18

CS-2054

Reaxys ID: 18302282

2-Buten-1-one, 1-(4-chlorophenyl)-3-[(3-hydroxyphenyl)amino]-, (2Z)-

SMER18,SMER-18

(Z)-1-(4-Chlorophenyl)-3-((3-hydroxyphenyl)amino)but-2-en-1-one

944153-47-3