ChemicalBook > CAS DataBase List > 2-Bromoacetophenone

2-Bromoacetophenone

Product Name
2-Bromoacetophenone
CAS No.
70-11-1
Chemical Name
2-Bromoacetophenone
Synonyms
PHENACYL BROMIDE;2-BROMO-1-PHENYLETHANONE;A-BROMOACETOPHENONE;1-Phenyl-2-broMoethanone;NSC 9807;Stauffer 4644;AKOS BBS-00004003;Bromoacetylbenzene;-Bromoacetophenone;PhenacylBromide>
CBNumber
CB6305185
Molecular Formula
C8H7BrO
Formula Weight
199.04
MOL File
70-11-1.mol
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2-Bromoacetophenone Property

Melting point:
48-51 °C (lit.)
Boiling point:
135 °C/18 mmHg (lit.)
Density 
1.476
refractive index 
1.5700 (estimate)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Crystals or Powder
color 
White to dark green-brown
Water Solubility 
PRACTICALLY INSOLUBLE
Merck 
14,1402
BRN 
606474
Stability:
Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
InChIKey
LIGACIXOYTUXAW-UHFFFAOYSA-N
CAS DataBase Reference
70-11-1(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 2-bromo-1-phenyl-(70-11-1)
EPA Substance Registry System
Ethanone, 2-bromo-1-phenyl- (70-11-1)
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Safety

Hazard Codes 
C
Risk Statements 
34-20/21/22
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2645 6.1/PG 2
WGK Germany 
3
F 
8-19
Hazard Note 
Corrosive
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29143990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
115835
Product name
2-Bromoacetophenone
Purity
98%
Packaging
5g
Price
$39.2
Updated
2024/03/01
Sigma-Aldrich
Product number
115835
Product name
2-Bromoacetophenone
Purity
98%
Packaging
100g
Price
$92.5
Updated
2024/03/01
TCI Chemical
Product number
A5508
Product name
Phenacyl Bromide [for HPLC Labeling]
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$31
Updated
2024/03/01
TCI Chemical
Product number
B0535
Product name
Phenacyl Bromide
Purity
>98.0%(GC)
Packaging
25g
Price
$56
Updated
2024/03/01
Alfa Aesar
Product number
A15576
Product name
2-Bromoacetophenone, 98%
Packaging
25g
Price
$37.6
Updated
2023/06/20
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2-Bromoacetophenone Chemical Properties,Usage,Production

Chemical Properties

Off white-grey green crystaline powder

Uses

2-Bromoacetophenone is a brominated acteophenone derivative. 2-Bromoacetophenone has been shown to completely and irreversibly inactivate human liver aldehyde dehydrogenase (EC 1.2.1.3) isoenzymes E1 and E2. 2-Bromoacetophenone and its derivatives display some inhibitory activity on neutral protein tyrosine.inhibitors

Uses

It is used in preparation of crystalline esters from acids. 2-Bromoacetophenone is a complete and irreversible inactivator of human liver aldehyde dehydrogenase isoenzymes E1 and E2.

Definition

ChEBI: An alpha-bromoketone that is acetophenone substituted by a bromo group at position 2.

Synthesis Reference(s)

Journal of the American Chemical Society, 76, p. 5796, 1954 DOI: 10.1021/ja01651a061
Organic Syntheses, Coll. Vol. 2, p. 480, 1943
Synthetic Communications, 22, p. 1923, 1992 DOI: 10.1080/00397919208021322

General Description

A crystalline solid or a liquid with a sharp odor. Toxic by inhalation, ingestion and skin absorption. A severe eye irritant (a lachrymator). Used to make other chemicals.

Air & Water Reactions

Reacts slowly with moisture in air to form hydrogen bromide.

Reactivity Profile

2-Bromoacetophenone reacts slowly with metals causing mild corrosion.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Purification Methods

Crystallise the bromide from EtOH, MeOH or pet ether (b 80-100o). [Tanner J Org Chem 52 2142 1987, Beilstein 7 IV 649.]

2-Bromoacetophenone Preparation Products And Raw materials

Raw materials

Acetone Bromobenzene Government regulation

Preparation Products

A-BROMO-4-NITROACETOPHENONE HEXAMINE 1-[2-(4-CHLOROPHENYL)-1-(1-HYDROXY-1-PHENYLETHYL)ETHYL]-1,2,4-TRIAZOLE 3-(-Hydroxyphenethyl)-2-imino thiazolidine 4-PHENYL-1,2,3-THIADIAZOL-5-AMINE DIETHOXYMETHANE 1-Phenacylpyridinium bromide 5-AMINO-3-PHENYLISOXAZOLE 4-AMINO-ALPHA-TERT-BUTYLAMINE-3,5-DICHLOROACETOPHENONE 2-(2-iminothiazolidin-3-yl)-1-phenylethan-1-one monohydrobromide 4-Acetyloxy-3-acetyloxymethyl-(N-benzyl-N-tertbutylamino)acetophenone hydrochloride 2-Phenylindole N-[1-(hydroxymethyl)-2-(4-nitrophenyl)-2-oxoethyl]acetamide
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View Lastest Price from 2-Bromoacetophenone manufacturers

Wuhan Boyuan Import & Export Co., LTD
Product
α-Bromoacetophenone 70-11-1
Price
US $30.00-15.00/KG
Min. Order
10KG
Purity
99.50%
Supply Ability
100tons
Release date
2023-04-07
Hebei Yanxi Chemical Co., Ltd.
Product
2-Bromoacetophenone 70-11-1
Price
US $40.00-40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-13
Hebei Guanlang Biotechnology Co., Ltd.
Product
2-Bromoacetophenone 70-11-1
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-11-15

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