ChemicalBook > CAS DataBase List > Bis-PEG6-NHS ester

Bis-PEG6-NHS ester

Product Name
Bis-PEG6-NHS ester
CAS No.
1526718-98-8
Chemical Name
Bis-PEG6-NHS ester
Synonyms
BIS-PEG6-NHS;Di-NHS Ester-PEG6;Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate;4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester
CBNumber
CB63062418
Molecular Formula
C24H36N2O14
Formula Weight
576.55
MOL File
1526718-98-8.mol
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Bis-PEG6-NHS ester Property

solubility 
Soluble in DMSO, DCM
form 
Viscous Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0107647
Product name
Bis-PEG6-NHSester
Purity
≥97.0%
Packaging
100mg
Price
$230
Updated
2021/12/16
BroadPharm
Product number
BP-21681
Product name
Bis-PEG6-NHSester
Purity
98%
Packaging
100mg
Price
$250
Updated
2021/12/16
BroadPharm
Product number
BP-21681
Product name
Bis-PEG6-NHSester
Purity
98%
Packaging
500mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0107647
Product name
Bis-PEG6-NHSester
Purity
≥97.0%
Packaging
250mg
Price
$400
Updated
2021/12/16
BroadPharm
Product number
BP-21681
Product name
Bis-PEG6-NHSester
Purity
98%
Packaging
1g
Price
$460
Updated
2021/12/16
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Bis-PEG6-NHS ester Chemical Properties,Usage,Production

Description

Bis-PEG6-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Biological Activity

Bis-PEG6-NHS ester is a PROTAC bridge and belongs to the PEG class. It can be used to synthesize a range of PROTAC molecules. Also Bis-PEG6-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Bis-PEG6-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Bis-PEG6-NHS ester Suppliers

T&W GROUP
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View Lastest Price from Bis-PEG6-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Bis-PEG6-NHS ester 1526718-98-8
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-25

1526718-98-8, Bis-PEG6-NHS esterRelated Search:


  • BIS-PEG6-NHS
  • 4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester
  • Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate
  • Di-NHS Ester-PEG6
  • 1526718-98-8
  • C24H36N2O14