ChemicalBook > CAS DataBase List > Bis-PEG6-NHS ester

Bis-PEG6-NHS ester

Product Name: Bis-PEG6-NHS ester
CAS No.: 1526718-98-8
Chemical Name: Bis-PEG6-NHS ester
Synonyms: BIS-PEG6-NHS;Di-NHS Ester-PEG6;NHSOOCCH2CH2O-PEG5-CH2CH2COONHS ester;Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate;4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester
CBNumber: CB63062418
Molecular Formula: C24H36N2O14
Formula Weight: 576.55
MOL File: 1526718-98-8.mol

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Bis-PEG6-NHS ester Property

storage temp.: -20°C, sealed storage, away from moisture
solubility: Soluble in DMSO, DCM
form: Viscous Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0107647
Product name: Bis-PEG6-NHSester
Purity: ≥97.0%
Packaging: 100mg
Price: $230
Updated: 2021/12/16

BroadPharm

Product number: BP-21681
Product name: Bis-PEG6-NHSester
Purity: 98%
Packaging: 100mg
Price: $250
Updated: 2021/12/16

BroadPharm

Product number: BP-21681
Product name: Bis-PEG6-NHSester
Purity: 98%
Packaging: 500mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0107647
Product name: Bis-PEG6-NHSester
Purity: ≥97.0%
Packaging: 250mg
Price: $400
Updated: 2021/12/16

BroadPharm

Product number: BP-21681
Product name: Bis-PEG6-NHSester
Purity: 98%
Packaging: 1g
Price: $460
Updated: 2021/12/16

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Bis-PEG6-NHS ester Chemical Properties,Usage,Production

Description

Bis-PEG6-NHS ester is a PEG linker containing two NHS ester groups. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Biological Activity

Bis-PEG6-NHS ester is a PROTAC bridge and belongs to the PEG class. It can be used to synthesize a range of PROTAC molecules. Also Bis-PEG6-NHS ester is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Bis-PEG6-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bis-PEG6-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Bis-PEG6-NHS ester 1526718-98-8
Price: US $0.00/g
Min. Order: 5g
Purity: >98.00%
Supply Ability: 5g
Release date: 2024-03-25

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BIS-PEG6-NHS

4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1,22-bis(2,5-dioxo-1-pyrrolidinyl) ester

Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16,19-hexaoxadocosanedioate

Di-NHS Ester-PEG6

NHSOOCCH2CH2O-PEG5-CH2CH2COONHS ester

1526718-98-8

C24H36N2O14