ChemicalBook > CAS DataBase List > Aurora Kinase Inhibitor II

Aurora Kinase Inhibitor II

Product Name
Aurora Kinase Inhibitor II
CAS No.
331770-21-9
Chemical Name
Aurora Kinase Inhibitor II
Synonyms
IUN-70219;Aurora kinase inhibitor-2;Aurora kinase inhibitor-2, 10 mM in DMSO;N-(4-((6,7-Dimethoxyquinazolin-4-yl)amino)phenyl)benzamide;Benzamide, N-[4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenyl]-;inhibit,Aurora-A,Aurora kinase inhibitor2,Aurora Kinase,ATP-competitive,Aurora kinase inhibitor 2,Aurora kinase inhibitor-2,Aurora-B,Inhibitor
CBNumber
CB63136779
Molecular Formula
C23H20N4O3
Formula Weight
400.43
MOL File
331770-21-9.mol
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Aurora Kinase Inhibitor II Property

Boiling point:
518.6±50.0 °C(Predicted)
Density 
1.321±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMF:0.25(Max Conc. mg/mL);0.62(Max Conc. mM)
DMF:PBS(pH7.2) (1:2):0.33(Max Conc. mg/mL);0.82(Max Conc. mM)
DMSO:2.5(Max Conc. mg/mL);6.2(Max Conc. mM)
form 
A crystalline solid
pka
13.01±0.70(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17541
Product name
Aurora Kinase Inhibitor II
Purity
≥98%
Packaging
500μg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
17541
Product name
Aurora Kinase Inhibitor II
Purity
≥98%
Packaging
1mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
17541
Product name
Aurora Kinase Inhibitor II
Purity
≥98%
Packaging
5mg
Price
$477
Updated
2024/03/01
Cayman Chemical
Product number
17541
Product name
Aurora Kinase Inhibitor II
Purity
≥98%
Packaging
10mg
Price
$834
Updated
2024/03/01
AK Scientific
Product number
0067CQ
Product name
AuroraKinaseInhibitorII
Packaging
10mg
Price
$1026
Updated
2021/12/16
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Aurora Kinase Inhibitor II Chemical Properties,Usage,Production

Description

The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. Aurora kinase inhibitor II is a cell-permeable anilinoquinazoline that blocks the activity of Aurora A (IC50 = 0.39 μM). In MCF-7 cells, it blocks proliferation with an IC50 value of 1.25 μM.

Uses

Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively[1].

IC 50

Aurora A: 310 nM (IC50); Aurora B: 240 nM (IC50)

References

[1] Andrew A Mortlock, et al. Progress in the development of selective inhibitors of aurora kinases. Curr Top Med Chem. 2005;5(8):807-21. DOI:10.2174/1568026054637719
[2] Nicola M Heron, et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1320-3. DOI:10.1016/j.bmcl.2005.11.053

Aurora Kinase Inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

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Aurora Kinase Inhibitor II Suppliers

China 30 United States 5 USA 1 Global 36
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331770-21-9, Aurora Kinase Inhibitor IIRelated Search:


  • Aurora kinase inhibitor-2
  • IUN-70219
  • N-(4-((6,7-Dimethoxyquinazolin-4-yl)amino)phenyl)benzamide
  • inhibit,Aurora-A,Aurora kinase inhibitor2,Aurora Kinase,ATP-competitive,Aurora kinase inhibitor 2,Aurora kinase inhibitor-2,Aurora-B,Inhibitor
  • Benzamide, N-[4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenyl]-
  • Aurora kinase inhibitor-2, 10 mM in DMSO
  • 331770-21-9