ML-031
- Product Name
- ML-031
- CAS No.
- 852230-33-2
- Chemical Name
- ML-031
- Synonyms
- ML-031;CYM-5482;1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione;2,5-Pyrrolidinedione, 1-[2-[2,5-dimethyl-1-(phenylmethyl)-1H-pyrrol-3-yl]-2-oxoethyl]-;cancer,LPL Receptor,Inhibitor,ML031,inhibit,S1PR2,CYM-5482,CYM 5482,CYM5482,Lysophospholipid Receptor,ML 031
- CBNumber
- CB63152681
- Molecular Formula
- C19H20N2O3
- Formula Weight
- 324.3737
- MOL File
- 852230-33-2.mol
ML-031 Property
- Boiling point:
- 568.8±50.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤5mg/ml in ethanol;5mg/ml in DMSO
- form
- crystalline solid
- pka
- -1.75±0.20(Predicted)
- color
- Light brown to brown
N-Bromosuccinimide Price
- Product number
- 15171
- Product name
- ML-031
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 15171
- Product name
- ML-031
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- 15171
- Product name
- ML-031
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 15171
- Product name
- ML-031
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $374
- Updated
- 2024/03/01
- Product number
- C5718
- Product name
- ML-031
- Packaging
- 5mg
- Price
- $133
- Updated
- 2021/12/16
ML-031 Chemical Properties,Usage,Production
Uses
CYM-5482 is a potent and selective agonist Sphingosine 1-phosphate receptor 2 (S1PR2) with an IC50 and EC50 of 1.0 and 1.03 μM. CYM-5482 has the potential for the research of cancer diseases[1].
Definition
ChEBI: 1-[2-[2,5-dimethyl-1-(phenylmethyl)-3-pyrrolyl]-2-oxoethyl]pyrrolidine-2,5-dione is an aromatic ketone.
Biological Activity
ml-031 is an agonist of s1p2 with ec50 value of 1 μm [1].sphingosine 1-phosphate (s1p) is a bioactive lysophospholipid mediator mainly released from activated platelets and implicated in many biological responses, such as cell proliferation, migration, survival, and differentiation [1]. sphingolipids belong to a family of bioactive molecules with cell signaling properties. sphingosine 1-phosphate (s1p) is widely expressed on various tissues and cell types. s1p is a pleiotropic lysophospholipid mediator exists in plasma and is released in large amounts from activated platelets [1]. until now, five sphingosine-1-phosphate receptors (s1pr1-s1pr5) have been identified. s1pr4 and s1pr5 are prominently expressed in the immune and nervous systems, respectively. s1p functions by binding to five distinct g protein-coupled receptors, s1p1/edg-1, s1p2/edg-5, s1p3/edg-3, s1p4/edg-6, and s1p5/edg-8.ml-031 activated s1p2 with an ec50 value of 1 μm in a s1p reporter assay [1].
References
[1] satsu h, schaeffer m t, guerrero m, et al. a sphingosine 1-phosphate receptor 2 selective allosteric agonist[j]. bioorganic & medicinal chemistry, 2013, 21(17): 5373-5382.
ML-031 Preparation Products And Raw materials
Raw materials
Preparation Products
ML-031 Suppliers
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