AZD-5904

Product Name: AZD-5904
CAS No.: 618913-30-7
Chemical Name: AZD-5904
Synonyms: AZD-5904;AZ1;TX4;AZD5904;AZD5904 (AZD 5904;AZD5904, 10 mM in DMSO;AZD5904,AZD-5904,Inhibitor,AZD 5904,Glutathione Peroxidase,inhibit;(R)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one;6H-Purin-6-one, 1,2,3,9-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo-
CBNumber: CB63366266
Molecular Formula: C10H12N4O2S
Formula Weight: 252.29
MOL File: 618913-30-7.mol

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AZD-5904 Property

Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: dmso:22.73(Max Conc. mg/mL);90.09(Max Conc. mM)
form: A solid
pka: 8.53±0.20(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3274
Product name: AZD5904
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $84.93
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3274
Product name: AZD5904
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $360
Updated: 2025/07/31

TRC

Product number: T294316
Product name: (S)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one
Packaging: 5mg
Price: $285
Updated: 2021/12/16

ChemScene

Product number: CS-0035112
Product name: AZD5904
Purity: 99.78%
Packaging: 5mg
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-0035112
Product name: AZD5904
Purity: 99.78%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

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AZD-5904 Chemical Properties,Usage,Production

Uses

(S)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,7-tetrahydro-6H-purin-6-one is used as an internal standard and also as an analytical standard.

Biological Activity

AZD5904 (TX4) is an orally active 2-thioxanthine class suicide substrate th at targets myeloperoxidase (MPO) for mechanism-based inactivation, covalently modifying MPO heme group without converting the enzyme to compound II. AZD5904 effectively inhibits peroxide-induced human MPO chlorination activity (IC50 = 0.2 μM) and extracellular MPO activity in PMA-stimulated human neutrophil cultures (by 68% at 1 μM). Oral administration (20-180 μmol/kg) of the racemate (TX3) is efficacious in reducing inflammation site MPO activity in mice in vivo with 10- to 19-fold selectivity over lactoperoxidase (LPO), thyroid peroxidase (TPO), and >70-fold selectivity over a panel of other enzymes, ion channels, and receptors.

AZD-5904 Preparation Products And Raw materials

Raw materials

Preparation Products

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AZD-5904 Suppliers

China 32 United States 7 Global 39

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618913-30-7, AZD-5904Related Search:

AZD-5904

AZD5904 (AZD 5904

AZ1;TX4;AZD5904

6H-Purin-6-one, 1,2,3,9-tetrahydro-3-[[(2R)-tetrahydro-2-furanyl]methyl]-2-thioxo-

(R)-3-((Tetrahydrofuran-2-yl)methyl)-2-thioxo-1,2,3,9-tetrahydro-6H-purin-6-one

AZD5904,AZD-5904,Inhibitor,AZD 5904,Glutathione Peroxidase,inhibit

AZD5904, 10 mM in DMSO

618913-30-7