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E3 ligase Ligand-Linker Conjugates 11

Product Name
E3 ligase Ligand-Linker Conjugates 11
CAS No.
1835705-61-7
Chemical Name
E3 ligase Ligand-Linker Conjugates 11
Synonyms
(S,R,S)-AHPC-6-5-6-Cl;(S,R,S)-AHPC-(C3-PEG)2-C6-C;VHL Ligand-Linker Conjugates 11;E3 ligase Ligand-Linker Conjugates 11;(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride;L-Prolinamide, N-[6-[[5-[(6-chlorohexyl)oxy]pentyl]oxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-[(2S)-2-[6-({5-[(6-chlorohexyl)oxy]pentyl}oxy)hexanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber
CB63386464
Molecular Formula
C39H61ClN4O6S
Formula Weight
749.44
MOL File
1835705-61-7.mol
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E3 ligase Ligand-Linker Conjugates 11 Property

Boiling point:
921.3±65.0 °C(Predicted)
Density 
1.152±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.08±0.40(Predicted)
form 
Solid
color 
Off-white to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
905402
Product name
(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride
Purity
95%
Packaging
50MG
Price
$559
Updated
2023/06/20
Iris Biotech GmbH
Product number
PTC1760
Product name
(S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl-Cl
Packaging
50mg
Price
$634.5
Updated
2021/12/16
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E3 ligase Ligand-Linker Conjugates 11 Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 11 Preparation Products And Raw materials

Raw materials

Preparation Products

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E3 ligase Ligand-Linker Conjugates 11 Suppliers

China 14 United States 3 Global 17
Sigma-Aldrich
Tel
021-61415566 800-8193336
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orderCN@merckgroup.com
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China
ProdList
51456
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80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4824
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58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
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1927928688@qq.com
Country
China
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1456
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
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sales@chemegen.com
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China
ProdList
11217
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58
Shanghai hongqu biomedical technology co. LTD
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88888888888
Email
hongquchem@qq.com
Country
China
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5132
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58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40037
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58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
ProdList
10035
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View Lastest Price from E3 ligase Ligand-Linker Conjugates 11 manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
(S,R,S)-AHPC-6-5-6-Cl 1835705-61-7
Price
US $0.00/g
Min. Order
1g
Purity
>95.00%
Supply Ability
1g
Release date
2024-04-01

1835705-61-7, E3 ligase Ligand-Linker Conjugates 11Related Search:

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  • E3 ligase Ligand-Linker Conjugates 11
  • (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl chloride
  • VHL Ligand-Linker Conjugates 11
  • L-Prolinamide, N-[6-[[5-[(6-chlorohexyl)oxy]pentyl]oxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
  • (S,R,S)-AHPC-6-5-6-Cl
  • (S,R,S)-AHPC-(C3-PEG)2-C6-C
  • (2S,4R)-1-[(2S)-2-[6-({5-[(6-chlorohexyl)oxy]pentyl}oxy)hexanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
  • 1835705-61-7
  • C39H61ClN4O6S