Heptaethylene Glycol Monomethyl Ether

Product Name: Heptaethylene Glycol Monomethyl Ether
CAS No.: 4437-01-8
Chemical Name: Heptaethylene Glycol Monomethyl Ether
Synonyms: 2,5,8,11,14,17,20-Heptaoxadocosan-22-ol;mPEG7;MPEG7-OH;m-PEG7-alcohol;926630;MEO-PEG(7)-OH;HO-(CH2CH2O)7-Me;Methyl-PEG7-alcohol;MONOMETHOXY-PEG (N=7);METHOXYHEPTAETHYLENE GLYCOL
CBNumber: CB6362485
Molecular Formula: C15H32O8
Formula Weight: 340.41
MOL File: 4437-01-8.mol

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Heptaethylene Glycol Monomethyl Ether Property

Boiling point:: 150 °C(Press: 0.005 Torr)
Density: 1.09
refractive index: 1.4540-1.4580
storage temp.: -20°C
form: clear liquid
pka: 14.36±0.10(Predicted)
color: Colorless to Light yellow to Light orange
InChI: InChI=1S/C15H32O8/c1-17-4-5-19-8-9-21-12-13-23-15-14-22-11-10-20-7-6-18-3-2-16/h16H,2-15H2,1H3
InChIKey: AGWKUHGLWHMYTG-UHFFFAOYSA-N
SMILES: C(O)COCCOCCOCCOCCOCCOCCOC
CAS DataBase Reference: 4437-01-8(CAS DataBase Reference)

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Safety

WGK Germany: 3
HS Code: 29094990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 41749
Product name: O-Methyl-heptaethylene glycol
Purity: ≥95% (oligomer purity)
Packaging: 1G
Price: $130.2
Updated: 2025/07/31

TCI Chemical

Product number: H1046
Product name: Heptaethylene Glycol Monomethyl Ether
Purity: >97.0%(GC)
Packaging: 1g
Price: $108
Updated: 2025/07/31

TCI Chemical

Product number: H1046
Product name: Heptaethylene Glycol Monomethyl Ether
Purity: >97.0%(GC)
Packaging: 5g
Price: $373
Updated: 2025/07/31

AK Scientific

Product number: J96803
Product name: Heptaethylene Glycol Monomethyl Ether
Packaging: 1g
Price: $95
Updated: 2021/12/16

Chem-Impex

Product number: 41730
Product name: Heptaethyleneglycolmonomethylether,97%(GC)
Purity: 97%(GC)
Packaging: 1G
Price: $145.6
Updated: 2021/12/16

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Heptaethylene Glycol Monomethyl Ether Chemical Properties,Usage,Production

Description

m-PEG7-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Definition

The presence of heptaethylene glycol monomethyl ether (HGME) as a process impurity and degradation impurity in the final purified form of Benzonatate is a determining factor in establishing the safety, identity, strength, purity, and quality of the drug substance. Owing to the cutaneous toxicity of HGME in the BNZ drug substance, a suitable and selective analysis method is required for its quantitation[1].

reaction suitability

reagent type: cross-linking reagent

Synthesis

112-60-7

74654-05-0

4437-01-8

A 60% NaH dispersion in mineral oil was added in batches to a stirred solution of triacetylene glycol (35.7 mmol) in anhydrous DMF (25.7 mL) under nitrogen protection, and the mixture was stirred for 1 hour at room temperature. Subsequently, a solution of 2-(2-(2-methoxyethoxy)ethoxy)ethyl methanesulfonate (23.36 mmol) in anhydrous DMF (4 mL) was added in a single addition to the resulting salt, and stirring was continued for 3.5 hours at room temperature. The progress of the reaction was monitored by thin layer chromatography (TLC with 12% unfolding agent ratio). Upon completion of the reaction, the reaction mixture was diluted with an equal volume of 1N HCl, extracted with ethyl acetate (2 x 20 mL) and the organic phase discarded. The aqueous phase was extracted and post-treated to give heptaglycol monomethyl ether in 82-84% yield.

IC 50

PEGs

References

[1] Lakshmi Narasimha Rao Katakam, Vishnu Murthy Marisetti, Santhosh Kumar Ettaboina. “Development and validation of LC–MS method for the determination of heptaethylene glycol monomethyl ether in benzonatate bulk drugs.” Biomedical Chromatography 35 7 (2021).

Heptaethylene Glycol Monomethyl Ether Preparation Products And Raw materials

Raw materials

Preparation Products

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Heptaethylene Glycol Monomethyl Ether Suppliers

Americas 1 China 159 Europe 1 France 1 Germany 2 India 3 Japan 1 Sweden 1 Switzerland 1 United Kingdom 1 United States 18 Global 189

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View Lastest Price from Heptaethylene Glycol Monomethyl Ether manufacturers

LAURENT

Product: mPEG7-OH 4437-01-8
Price: US $4788.00/kg
Min. Order: 0.5kg
Purity: 98%
Supply Ability: 300kg
Release date: 2025-11-15

XIAMEN SINOPEG BIOTECH CO., LTD.

Product: 2,5,8,11,14,17,20-heptaoxadocosan-22-ol 4437-01-8
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
Release date: 2025-09-10

Hebei Chuanghai Biotechnology Co., Ltd

Product: HEPTAETHYLENE GLYCOL MONOMETHYL ETHER 4437-01-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

4437-01-8, Heptaethylene Glycol Monomethyl Ether Related Search:

1-{2-[2-(2-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-2-methoxy-ethane mPEG6-CH2COOH 2,5,8,11,14,17,20-Heptaoxadocosane-22-thiol m-PEG7-aldehyde Polyethylene Glycol Monocetyl Ether POLYETHYLENE GLYCOL MONO-4-NONYLPHENYL ETHER NONAETHYLENE GLYCOL MONODODECYL ETHER C10 E8 C14E8 Dicyclohexano-24-crown-8 C12E8 HEPTAETHYLENE GLYCOL MONODODECYL ETHER POLY(ETHYLENE GLYCOL) (N) MONOMETHACRYLATE Polyoxyethylene lauryl ether C16 E8 Benzonatate Polyoxyethylene stearate HEPTAETHYLENE GLYCOL

Heptaetheylene glycol methyl ether

mPEG7

HEPTAETHYLENE GLYCOL MONOMETHYL ETHER

Methoxyheptaethylene glycol, Monomethoxy-PEG (n=7)

MPEG7-OH

Heptaetheylene glycol MonoMethyl ether

2,5,8,11,14,17,20-Heptaoxadocosan-22-ol

3,6,9,12,15,18,21-heptaoxadocosan-1-ol

m-PEG7-alcohol

Methyl-PEG7-alcohol

O-METHYL-HEPTAETHYLENE GLYCOL

MONOMETHOXY-PEG (N=7)

METHOXYHEPTAETHYLENE GLYCOL

MEO-PEG(7)-OH

HEPTA(ETHYLENE GLYCOL) METHYL ETHER

926630

2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

HeptaethyleneGlycolMonomethylEther&gt

HEPTAETHYLENE GLYCOL MONOMETHYL ETHER ISO 9001：2015 REACH

HO-(CH2CH2O)7-Me

mPEG7-OH/Heptaethylene Glycol Monomethyl Ether

<i>O</i>-Methyl-heptaethylene glycol

2,5,8,11,14,17,20-Heptaoxadocosan-22-ol 97%min

4437-01-8

926-63-0

4377-01-8

HOCH2CH2O7CH3

C15H32O8

Monofunctional Ethylene Glycols

Ethylene Glycols & Monofunctional Ethylene Glycols

Peptide Synthesis

Peptide PEGylation

Specialty Synthesis

High Oligomer Purity PEG

Chemical Biology

Chemical Synthesis

High Oligomer Purity PEG

PEGylation

Monofunctional Ethylene Glycols

Ethylene Glycols & Monofunctional Ethylene Glycols

PEG-COOH

peg