4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid

Product Name: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
CAS No.: 29553-70-6
Chemical Name: 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
Synonyms: 4-CPPC (4CPPC);4-CPPC, 10 mM in DMSO;4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid;4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid;2,5-Pyridinedicarboxylic acid, 4-(3-carboxyphenyl)-
CBNumber: CB64108052
Molecular Formula: C14H9NO6
Formula Weight: 287.22
MOL File: 29553-70-6.mol

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4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Property

storage temp.: Store at -20°C
solubility: DMSO: soluble
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30068
Product name: 4-CPPC
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 30068
Product name: 4-CPPC
Packaging: 10mg
Price: $486
Updated: 2024/03/01

Cayman Chemical

Product number: 30068
Product name: 4-CPPC
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 30068
Product name: 4-CPPC
Packaging: 5mg
Price: $275
Updated: 2024/03/01

AK Scientific

Product number: 0509CE
Product name: 4-(3-Carboxyphenyl)pyridine-2,5-dicarboxylicAcid
Packaging: 5mg
Price: $403
Updated: 2021/12/16

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4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Chemical Properties,Usage,Production

Uses

4-CPPC is a potent, reversible and selective MIF-2 inhibitor with Ki values of 431, 33 μM for MIF-1, MIF-2, respectively[1].

Biological Activity

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50 = 27 μM).1 It is selective for MIF-2 over MIF-1 (IC50 = 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.

References

1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)

4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Preparation Products And Raw materials

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29553-70-6, 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acidRelated Search:

4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid

4-CPPC (4CPPC)

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4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid

4-CPPC, 10 mM in DMSO

29553-70-6