ChemicalBook > CAS DataBase List > 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
- Product Name
- 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
- CAS No.
- 29553-70-6
- Chemical Name
- 4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid
- Synonyms
- 4-CPPC (4CPPC);4-CPPC, 10 mM in DMSO;4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid;4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid;2,5-Pyridinedicarboxylic acid, 4-(3-carboxyphenyl)-
- CBNumber
- CB64108052
- Molecular Formula
- C14H9NO6
- Formula Weight
- 287.22
- MOL File
- 29553-70-6.mol
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4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A crystalline solid
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 30068
- Product name
- 4-CPPC
- Packaging
- 1mg
- Price
- $61
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30068
- Product name
- 4-CPPC
- Packaging
- 10mg
- Price
- $486
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30068
- Product name
- 4-CPPC
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 30068
- Product name
- 4-CPPC
- Packaging
- 5mg
- Price
- $275
- Updated
- 2024/03/01
AK Scientific
- Product number
- 0509CE
- Product name
- 4-(3-Carboxyphenyl)pyridine-2,5-dicarboxylicAcid
- Packaging
- 5mg
- Price
- $403
- Updated
- 2021/12/16
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4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Chemical Properties,Usage,Production
Uses
4-CPPC is a potent, reversible and selective MIF-2 inhibitor with Ki values of 431, 33 μM for MIF-1, MIF-2, respectively[1].
Biological Activity
4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50 = 27 μM).1 It is selective for MIF-2 over MIF-1 (IC50 = 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.
References
1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)
4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Suppliers
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