4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid

4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Property

storage temp. 

Store at -20°C

solubility 

DMSO: soluble

form 

A crystalline solid

color 

White to off-white

Hazard and Precautionary Statements (GHS)

4-(3-carboxyphenyl)pyridine-2,5-dicarboxylic acid Chemical Properties,Usage,Production

Uses

4-CPPC is a potent, reversible and selective MIF-2 inhibitor with Ki values of 431, 33 μM for MIF-1, MIF-2, respectively[1].

Biological Activity

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50 = 27 μM).1 It is selective for MIF-2 over MIF-1 (IC50 = 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.

References

1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)