ChemicalBook > CAS DataBase List > (E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide

Product Name
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
CAS No.
15533-09-2
Chemical Name
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
Synonyms
Compound C108;Compound C108 >=98% (HPLC);Compound C108,Compound C-108;Compound C108, 10 mM in DMSO;2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide;2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide;(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide;2-hydroxy-benzoicacid,2-[1-(2-hydroxyphenyl)ethylidene]hydrazide;Benzoic acid, 2-hydroxy-, 2-[1-(2-hydroxyphenyl)ethylidene]hydrazide
CBNumber
CB64154983
Molecular Formula
C15H14N2O3
Formula Weight
270.28
MOL File
15533-09-2.mol
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(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Property

Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF:1.0(Max Conc. mg/mL);3.7(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);3.7(Max Conc. mM)
form 
powder
pka
8.27±0.35(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2017
Product name
Compound C108
Purity
≥98% (HPLC)
Packaging
5mg
Price
$108
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2017
Product name
Compound C108
Purity
≥98% (HPLC)
Packaging
25mg
Price
$242.9
Updated
2025/07/31
Cayman Chemical
Product number
9002951
Product name
Compound C108
Purity
≥98%
Packaging
500μg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
9002951
Product name
Compound C108
Purity
≥98%
Packaging
1mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
9002951
Product name
Compound C108
Purity
≥98%
Packaging
5mg
Price
$575
Updated
2024/03/01
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(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Chemical Properties,Usage,Production

Uses

2-Hydroxy-benzoic Acid [1-(2-Hydroxyphenyl)ethylidene]hydrazide is a GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) inhibitor. G3BP2 is involved with breast tumor initiation.

Biochem/physiol Actions

C108 is a small molecule that exhibits cancer-selective cytotoxicity (Viability = 100%/MCF-10A vs. 50%/BT-474, 67%/4T1, 70%/MDA-MB-231 & MDA-MB-453 post 48 h 1 μM C108 treatment) and synergizes with low dose paclitaxel in reducing ALDH-positive tumor-initiating cells (TIC poulation = 56.6%/control, 60.6%/0.1 μM paclitaxel alone, 47.4%/1 μM C108 alone, 7.3%/combined treatment for 24 h in BT474 breast cancer cultures) by targeting stress granule-associated protein G3BP2 (GAP SH3 domain-binding protein 2). Likewise, C108 pretreatment prior to xenografting greatly reduces BT-474 tumor-initiating frequency (from 1/175 to 1/1103 by limiting dilution xenograft assays) in mice in vivo. G3BP2 is reported to bind and stabilize SART3 mRNA, thereby indirectly regulating the core pluripotency transcription factors Oct-4 and Nanog critically involved in ESC self-renewal and breast tumor initiation.

in vivo

Compound C108 (1 μM; 24 h) targets and decreases tumor initiating cells (TICs), while injected BT-474 cells treated with Compound C108 into the mammary fat pad of female nonobese diabetic/severe combined immune deficiency (NOD-SCID) mice in a limiting-dilution xenograft assay[1].

(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Suppliers

China 25 Finland 2 United States 4 Global 31
Sigma-Aldrich
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15533-09-2, (E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazideRelated Search:


  • (E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
  • Compound C108
  • Compound C108 >=98% (HPLC)
  • Compound C108,Compound C-108
  • Benzoic acid, 2-hydroxy-, 2-[1-(2-hydroxyphenyl)ethylidene]hydrazide
  • 2-hydroxy-benzoicacid,2-[1-(2-hydroxyphenyl)ethylidene]hydrazide
  • 2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
  • Compound C108, 10 mM in DMSO
  • 2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
  • 15533-09-2