(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
- Product Name
- (E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
- CAS No.
- 15533-09-2
- Chemical Name
- (E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide
- Synonyms
- Compound C108;Compound C108 >=98% (HPLC);Compound C108,Compound C-108;Compound C108, 10 mM in DMSO;2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide;2-Hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide;(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide;2-hydroxy-benzoicacid,2-[1-(2-hydroxyphenyl)ethylidene]hydrazide;Benzoic acid, 2-hydroxy-, 2-[1-(2-hydroxyphenyl)ethylidene]hydrazide
- CBNumber
- CB64154983
- Molecular Formula
- C15H14N2O3
- Formula Weight
- 270.28
- MOL File
- 15533-09-2.mol
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Property
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF:1.0(Max Conc. mg/mL);3.7(Max Conc. mM)
DMSO:1.0(Max Conc. mg/mL);3.7(Max Conc. mM) - form
- powder
- pka
- 8.27±0.35(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML2017
- Product name
- Compound C108
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $108
- Updated
- 2025/07/31
- Product number
- SML2017
- Product name
- Compound C108
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $242.9
- Updated
- 2025/07/31
- Product number
- 9002951
- Product name
- Compound C108
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 9002951
- Product name
- Compound C108
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 9002951
- Product name
- Compound C108
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $575
- Updated
- 2024/03/01
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Chemical Properties,Usage,Production
Uses
2-Hydroxy-benzoic Acid [1-(2-Hydroxyphenyl)ethylidene]hydrazide is a GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2) inhibitor. G3BP2 is involved with breast tumor initiation.
Biochem/physiol Actions
C108 is a small molecule that exhibits cancer-selective cytotoxicity (Viability = 100%/MCF-10A vs. 50%/BT-474, 67%/4T1, 70%/MDA-MB-231 & MDA-MB-453 post 48 h 1 μM C108 treatment) and synergizes with low dose paclitaxel in reducing ALDH-positive tumor-initiating cells (TIC poulation = 56.6%/control, 60.6%/0.1 μM paclitaxel alone, 47.4%/1 μM C108 alone, 7.3%/combined treatment for 24 h in BT474 breast cancer cultures) by targeting stress granule-associated protein G3BP2 (GAP SH3 domain-binding protein 2). Likewise, C108 pretreatment prior to xenografting greatly reduces BT-474 tumor-initiating frequency (from 1/175 to 1/1103 by limiting dilution xenograft assays) in mice in vivo. G3BP2 is reported to bind and stabilize SART3 mRNA, thereby indirectly regulating the core pluripotency transcription factors Oct-4 and Nanog critically involved in ESC self-renewal and breast tumor initiation.
in vivo
Compound C108 (1 μM; 24 h) targets and decreases tumor initiating cells (TICs), while injected BT-474 cells treated with Compound C108 into the mammary fat pad of female nonobese diabetic/severe combined immune deficiency (NOD-SCID) mice in a limiting-dilution xenograft assay[1].
(E)-2-hydroxy-N'-(1-(2-hydroxyphenyl)ethylidene)benzohydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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