Diethyl azodicarboxylate
- Product Name
- Diethyl azodicarboxylate
- CAS No.
- 1972-28-7
- Chemical Name
- Diethyl azodicarboxylate
- Synonyms
- DEAD;DAD;(E)-di-tert-butyl diazene-1,2-dicarboxylate;Diethyl diazene-1,2-dicarboxylate;(E)-diethyl diazene-1,2-dicarboxylate;Diethoxycarbonyldiazene;DiethylAzidoCarboxylate;diethyl azodicarboxylate solution;AZODICARBOXYLIC ACID DIETHYL ESTER;Ethyl (NE)-N-ethoxycarbonyliminocarbamate
- CBNumber
- CB6432076
- Molecular Formula
- C6H10N2O4
- Formula Weight
- 174.15
- MOL File
- 1972-28-7.mol
Diethyl azodicarboxylate Property
- Melting point:
- 6°C
- Boiling point:
- 106°C (13 mmHg)
- Density
- 1.106
- refractive index
- n20/D 1.47
- Flash point:
- 85°C
- storage temp.
- 2-8°C
- solubility
- Miscible with dichloromethane, diethyl ether and toluene.
- form
- liquid
- color
- Clear, orange
- Sensitive
- Air Sensitive
- BRN
- 908662
- Stability:
- Stable, but may explode if heated under confinement. May be shock sensitive. Decomposes vigorously if heated above 100 C. Incompatible with strong acids, strong bases, strong oxidizing agents, strong reducing agents. Light sensitive.
- InChI
- InChI=1S/C6H10N2O4/c1-3-11-5(9)7-8-6(10)12-4-2/h3-4H2,1-2H3
- InChIKey
- FAMRKDQNMBBFBR-FPLPWBNLSA-N
- SMILES
- N(C(OCC)=O)=NC(OCC)=O
- CAS DataBase Reference
- 1972-28-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Diethyl azo diformate(1972-28-7)
Safety
- Hazard Codes
- F,Xn,Xi
- Risk Statements
- 5-11-20-36/37/38-48/20-63-65-67-48/20/22-40-20/22-20/21/22-10
- Safety Statements
- 26-36/37-62-47-36-35
- RIDADR
- UN 3233 4.1
- WGK Germany
- 3
- F
- 9
- Hazard Note
- Toxic/Irritant/Flammable
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29270000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H242Heating may cause a fire
H304May be fatal if swallowed and enters airways
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H336May cause drowsiness or dizziness
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P331Do NOT induce vomiting.
P370+P378In case of fire: Use … for extinction.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P403+P235Store in a well-ventilated place. Keep cool.
N-Bromosuccinimide Price
- Product number
- 563110
- Product name
- Diethyl azodicarboxylate solution
- Purity
- 40 wt. % in toluene
- Packaging
- 25g
- Price
- $75.1
- Updated
- 2024/03/01
- Product number
- 563110
- Product name
- Diethyl azodicarboxylate solution
- Purity
- 40 wt. % in toluene
- Packaging
- 100g
- Price
- $246
- Updated
- 2024/03/01
- Product number
- L19348
- Product name
- Diethyl azodicarboxylate, 97%
- Packaging
- 5g
- Price
- $33.3
- Updated
- 2021/12/16
- Product number
- L19348
- Product name
- Diethyl azodicarboxylate, 97%
- Packaging
- 25g
- Price
- $92.6
- Updated
- 2021/12/16
- Product number
- L19348
- Product name
- Diethyl azodicarboxylate, 97%
- Packaging
- 100g
- Price
- $274
- Updated
- 2021/12/16
Diethyl azodicarboxylate Chemical Properties,Usage,Production
Chemical Properties
Clear orange to orange-red liquid
Uses
A fluorescent CDK inhibitor for treatment of cancer
Uses
Reactant for preparation of:
- Immunostimulants α-Galactosylceramides
- Cellotriose and cellotetraose analogues as transition state mimics for mechanistic studies of cellulases
- Bisubstrate inhibitors with molecular recognition at the active site of catechol-O-methyltransferase
- Derivatives of F200 and S383 with cannabinoid CB1 receptor binding activities
- Aza-β-lactams via NHC-catalyzed [2 + 2] cycloaddition with ketenes
Reagent for:
- Annulation of N-protected imines
- α-thiocyanation of enolizable ketones with ammonium thiocyanate
- Diels-Alder reactions
General Description
DOT Special Approval Submission is Under Review. Availability is Estimated as March 2012.
Purification Methods
Dissolve DEAD in toluene, wash it with 10% NaHCO3 till neutral (may require several washes if too much hydrolysis had occurred: check IR for OH bands), then wash with H2O (2x), dry over Na2SO4, filter, evaporate the toluene and distil it through a short Vigreux column (p 11) at as high a vacuum as possible. The main portion boils at 107-111o/15mm. Since it is likely to explode, use an oil bath for heating the still and all operations should be carried -out behind an adequate shield. [Rabjohn Org Synth Coll Vol III 375 1955, see Kauer Org Synth Coll Vol IV 412 1963]. [Beilstein 3 III 233.] It is commercially available as a 40% solution in toluene. This reagent is useful in the Mitsunobu reaction [Mitsunobu Synthesis 1 1981, Gennari et al. J Am Chem Soc 108 6394 1986, Evans et al. J Am Chem Soc 108 6394 1986, Hughes Org React 42 335 1992, Dodge et al. Org Synth 73 110 1996, Hughes Org Prep Proc Int 28 127 1996, Ferguson & Marcelle J Am Chem Soc 128 4576 2006; see also di-tert-butyl azodicarboxylate above and DIAD below]. § A polystyrene supported DEAD version is commercially available with a loading of ~1.2mmol/g.
Diethyl azodicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diethyl azodicarboxylate manufacturers
- Product
- Diethyl azodicarboxylate 1972-28-7
- Price
- US $120.00-115.00/kilograms
- Min. Order
- 10kilograms
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-03-01
- Product
- Diethyl azodicarboxylate 1972-28-7
- Price
- US $32.00-1.40/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-07
- Product
- Diethyl azodicarboxylate 1972-28-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2022-10-09